[ { "topicId": "CD000996", "task": "Intervention", "pmid": "27720881", "title": "Bronchiectasis Severity Is an Independent Risk Factor for Vascular Disease in a Bronchiectasis Cohort.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “A retrospective study of 400 patients attending a specialist bronchiectasis clinic”; source: title and abstract. Population: Yes; evidence: “patients with bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “receiving long-term statin therapy”; source: title and abstract. Comparator: No; evidence: “Independent factors associated with all-cause vascular disease”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “patients with bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "A retrospective study of 400 patients attending a specialist bronchiectasis clinic", "patients with bronchiectasis", "receiving long-term statin therapy", "Independent factors associated with all-cause vascular disease", "patients with bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "4209914", "title": "Chronic eosinophilic pneumonia, a manifestation of allergic aspergillosis.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: No abstract available; cannot determine study design.; source: title and abstract. Population: Maybe; evidence: No abstract available; cannot confirm population.; source: title and abstract. Intervention or exposure: Maybe; evidence: No abstract available; cannot confirm intervention.; source: title and abstract. Comparator: Maybe; evidence: No abstract available; cannot confirm comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No abstract available; cannot confirm exclusion of CF.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24625938", "title": "Role of inhaled amphotericin in allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The aim of this review is to study the utility of inhaled amphotericin in ABPA.”; source: title and abstract. Population: Yes; evidence: “Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by immune reactions mounted against the ubiquitous fungus Aspergillus fumigatus. The disease clinically manifests with poorly controlled asthma, hemoptysis, systemic manifestations like fever, anorexia and weight loss, fleeting pulmonary opacities and bronchiectasis.”; source: title and abstract. Intervention or exposure: No; evidence: “Nebulized amphotericin B has been used in the management of invasive pulmonary aspergillosis.”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by immune reactions mounted against the ubiquitous fungus Aspergillus fumigatus.”; source: title and abstract.", "evidenceQuotes": [ "The aim of this review is to study the utility of inhaled amphotericin in ABPA.", "Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by immune reactions mounted against the ubiquitous fungus Aspergillus fumigatus. The disease clinically manifests with poorly controlled asthma, hemoptysis, systemic manifestations like fever, anorexia and weight loss, fleeting pulmonary opacities and bronchiectasis.", "Nebulized amphotericin B has been used in the management of invasive pulmonary aspergillosis.", "Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by immune reactions mounted against the ubiquitous fungus Aspergillus fumigatus." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20635793", "title": "Successful use of rituximab in refractory idiopathic thrombocytopenic purpura in a patient with common variable immunodeficiency.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We describe a 36-year-old woman with CVID.”; source: title and abstract. Population: Yes; evidence: “The clinical course of her disease was complicated by bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “She received a total of 5 doses of rituximab (375 mg/m2)”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “common variable immunodeficiency (CVID)”; source: title and abstract.", "evidenceQuotes": [ "We describe a 36-year-old woman with CVID.", "The clinical course of her disease was complicated by bronchiectasis", "She received a total of 5 doses of rituximab (375 mg/m2)", "common variable immunodeficiency (CVID)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7638431", "title": "[The use of high resolution x-ray computed tomography in the diagnosis of hypersensitivity pneumopathy to gold salts. Apropos of a case].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The authors present a case of pneumonitis induced by gold”; source: title and abstract. Population: Yes; evidence: “accompanied by significant bronchial distortion and bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “pneumonitis induced by gold”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “hypersensitivity pneumonia is rare during gold therapy”; source: title and abstract.", "evidenceQuotes": [ "The authors present a case of pneumonitis induced by gold", "accompanied by significant bronchial distortion and bronchiectasis", "pneumonitis induced by gold", "hypersensitivity pneumonia is rare during gold therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26575791", "title": "Utility of IgE (total and Aspergillus fumigatus specific) in monitoring for response and exacerbations in allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “patients of ABPA (acute stage) with pulmonary infiltrates and bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “after 8 weeks of glucocorticoid therapy”; source: title and abstract. Comparator: No; evidence: “underwent measurement of total and A. fumigatus specific IgE at baseline, after 8 weeks of glucocorticoid therapy, and during exacerbations”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “patients of ABPA (acute stage) with pulmonary infiltrates and bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "patients of ABPA (acute stage) with pulmonary infiltrates and bronchiectasis", "after 8 weeks of glucocorticoid therapy", "underwent measurement of total and A. fumigatus specific IgE at baseline, after 8 weeks of glucocorticoid therapy, and during exacerbations", "patients of ABPA (acute stage) with pulmonary infiltrates and bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25354514", "title": "The clinical spectrum of pulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host.”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: No; evidence: “The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host.”; source: title and abstract. Comparator: No; evidence: “The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host.”; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “Allergic bronchopulmonary aspergillosis affects patients with asthma and cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host.", "The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host.", "The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host.", "Allergic bronchopulmonary aspergillosis affects patients with asthma and cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19995143", "title": "Methotrexate: can it be a choice for nasal polyposis in aspirin exacerbated respiratory disease?", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We report two patients whose NP dramatically reduced in size after a course of MTX therapy administered as an additional treatment for their steroid- dependent asthma.”; source: title and abstract. Population: No; evidence: “Nasal polyposis (NP) is considered a subgroup of chronic rhinosinusitis and is commonly associated with asthma, bronchiectasis, and cystic fibrosis.”; source: title and abstract. Intervention or exposure: No; evidence: “after a course of MTX therapy administered as an additional treatment for their steroid- dependent asthma”; source: title and abstract. Comparator: No; evidence: “We report two patients whose NP dramatically reduced in size after a course of MTX therapy”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Nasal polyposis (NP) is considered a subgroup of chronic rhinosinusitis and is commonly associated with asthma, bronchiectasis, and cystic fibrosis.”; source: title and abstract.", "evidenceQuotes": [ "We report two patients whose NP dramatically reduced in size after a course of MTX therapy administered as an additional treatment for their steroid- dependent asthma.", "Nasal polyposis (NP) is considered a subgroup of chronic rhinosinusitis and is commonly associated with asthma, bronchiectasis, and cystic fibrosis.", "after a course of MTX therapy administered as an additional treatment for their steroid- dependent asthma", "We report two patients whose NP dramatically reduced in size after a course of MTX therapy", "Nasal polyposis (NP) is considered a subgroup of chronic rhinosinusitis and is commonly associated with asthma, bronchiectasis, and cystic fibrosis." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1763005", "title": "[Fibrosing alveolitis in a 7-year-old girl with autoimmune hemolytic anemia and autoimmune hepatitis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “bronchiectases in the region of the left lower lobe were confirmed by bronchography”; source: title and abstract. Intervention or exposure: No; evidence: “treatment with decortin and imurek”; source: title and abstract. Comparator: No; evidence: “An attempt to discontinue the medication at 5 1/2 years of age resulted in a histologically confirmed recurrence”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "bronchiectases in the region of the left lower lobe were confirmed by bronchography", "treatment with decortin and imurek", "An attempt to discontinue the medication at 5 1/2 years of age resulted in a histologically confirmed recurrence" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10193374", "title": "Increased levels of exhaled carbon monoxide in bronchiectasis: a new marker of oxidative stress.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “The levels of exhaled CO of 42 non-smoking patients with bronchiectasis treated or not treated with inhaled corticosteroids were compared with CO levels in 37 normal non-smoking subjects.”; source: title and abstract. Population: Yes; evidence: “42 non-smoking patients with bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “treated or not treated with inhaled corticosteroids”; source: title and abstract. Comparator: Yes; evidence: “treated or not treated with inhaled corticosteroids”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non-smoking patients with bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "The levels of exhaled CO of 42 non-smoking patients with bronchiectasis treated or not treated with inhaled corticosteroids were compared with CO levels in 37 normal non-smoking subjects.", "42 non-smoking patients with bronchiectasis", "treated or not treated with inhaled corticosteroids", "treated or not treated with inhaled corticosteroids", "non-smoking patients with bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1411394", "title": "[Pulmonary changes in ulcerative colitis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report on a 54-year-old patient who developed symptoms of bronchitis 3 months after colectomy for ulcerative colitis.”; source: title and abstract. Population: Yes; evidence: “Bronchiectases were documented by high resolution computer lung scan.”; source: title and abstract. Intervention or exposure: No; evidence: “Our patient was treated with oral and topical corticosteroids.”; source: title and abstract. Comparator: No; evidence: “Our patient was treated with oral and topical corticosteroids.”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report on a 54-year-old patient who developed symptoms of bronchitis 3 months after colectomy for ulcerative colitis.", "Bronchiectases were documented by high resolution computer lung scan.", "Our patient was treated with oral and topical corticosteroids.", "Our patient was treated with oral and topical corticosteroids." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23616969", "title": "Update on clinical inflammometry for the management of airway diseases.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Update on clinical inflammometry for the management of airway diseases.”; source: title and abstract. Population: Maybe; evidence: Discusses airway diseases including bronchiectasis, but not specifically stable bronchiectasis without CF.; source: title and abstract. Intervention or exposure: Maybe; evidence: Mentions corticosteroids but not specifically inhaled corticosteroids as regular treatment.; source: title and abstract. Comparator: Maybe; evidence: No specific comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Update on clinical inflammometry for the management of airway diseases." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20720607", "title": "Sulphasalazine lung toxicity: report of two cases.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “report of two cases”; source: title and abstract. Population: Maybe; evidence: Title mentions lung toxicity, but no details on bronchiectasis or CF.; source: title and abstract. Intervention or exposure: No; evidence: “Sulphasalazine lung toxicity”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "report of two cases", "Sulphasalazine lung toxicity" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20831464", "title": "Measured immunoglobulin E in allergic bronchopulmonary aspergillosis treated with omalizumab.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “describe the clinical course and serial measured IgE levels in two adult patients”; source: title and abstract. Population: Yes; evidence: “bilateral bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “treated with omalizumab”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "describe the clinical course and serial measured IgE levels in two adult patients", "bilateral bronchiectasis", "treated with omalizumab" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19905965", "title": "Unilateral ureteral obstruction caused by Aspergillus, subgenus Nidulantes in a patient on steroid therapy: a case report and review of the literature.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “a case report and review of the literature”; source: title and abstract. Population: Yes; evidence: “chronic obstructive lung disease and bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid therapy for chronic obstructive lung disease and bronchiectasis”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "a case report and review of the literature", "chronic obstructive lung disease and bronchiectasis", "corticosteroid therapy for chronic obstructive lung disease and bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20393960", "title": "Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: Yes; evidence: “All randomised controlled trials comparing inhaled NSAIDs to a control group (placebo or usual treatment) in children or adults with bronchiectasis not related to cystic fibrosis.”; source: title and abstract. Population: Yes; evidence: “children or adults with bronchiectasis not related to cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “inhaled NSAIDs”; source: title and abstract. Comparator: Yes; evidence: “placebo or usual treatment”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “not related to cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "All randomised controlled trials comparing inhaled NSAIDs to a control group (placebo or usual treatment) in children or adults with bronchiectasis not related to cystic fibrosis.", "children or adults with bronchiectasis not related to cystic fibrosis", "inhaled NSAIDs", "placebo or usual treatment", "not related to cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "3107762", "title": "Smoke inhalation injury from newer synthetic building materials--a patient who survived 205 days.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 25-year-old factory worker sustained inhalation injury...”; source: title and abstract. Population: No; evidence: “acquired bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “Systemic administration of corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 25-year-old factory worker sustained inhalation injury...", "acquired bronchiectasis", "Systemic administration of corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16295752", "title": "Allergic bronchopulmonary aspergillosis--a case report.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 24 years old male presented with recurrent symptoms...”; source: title and abstract. Population: No; evidence: “central type bronchiectasus”; source: title and abstract. Intervention or exposure: No; evidence: “oral prednisolone”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 24 years old male presented with recurrent symptoms...", "central type bronchiectasus", "oral prednisolone" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24997131", "title": "Nebulized therapy. SEPAR year.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “In this review we focus solely on drugs currently used, or under investigation, for nebulization in adult patients”; source: title and abstract. Population: Maybe; evidence: “adult patients”; source: title and abstract. Intervention or exposure: Maybe; evidence: “inhaled steroids”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned; it is a review, so unclear.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "In this review we focus solely on drugs currently used, or under investigation, for nebulization in adult patients", "adult patients", "inhaled steroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20385626", "title": "Bolus methylprednisolone efficacy for uncontrolled exacerbation of cystic fibrosis in children.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present here the clinical course of 4 children with cystic fibrosis”; source: title and abstract. Population: No; evidence: “children with cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “high-dose short course of methylprednisolone”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “children with cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "We present here the clinical course of 4 children with cystic fibrosis", "children with cystic fibrosis", "high-dose short course of methylprednisolone", "children with cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23734824", "title": "Clinical case: Differential diagnosis of idiopathic pulmonary fibrosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This case report intends to demonstrate and discuss these difficulties”; source: title and abstract. Population: No; evidence: “The diagnosis of idiopathic pulmonary fibrosis can be quite challenging”; source: title and abstract. Intervention or exposure: No; evidence: “treatment included prednisolone, azathioprine, acetylcysteine”; source: title and abstract. Comparator: No; evidence: “treatment included prednisolone, azathioprine, acetylcysteine”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This case report intends to demonstrate and discuss these difficulties", "The diagnosis of idiopathic pulmonary fibrosis can be quite challenging", "treatment included prednisolone, azathioprine, acetylcysteine", "treatment included prednisolone, azathioprine, acetylcysteine" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "3704962", "title": "Effect of cigarette smoking, pulmonary inflammation, and lung disease on concentrations of carcinoembryonic antigen in serum and secretions.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A specific radioimmunoassay for carcinoembryonic antigen was used to investigate aspects of its measurement in lung disease.”; source: title and abstract. Population: No; evidence: “patients with chronic obstructive bronchitis”; source: title and abstract. Intervention or exposure: No; evidence: “Corticosteroid treatment reduced the concentration in nine patients with bronchitis”; source: title and abstract. Comparator: No; evidence: “Corticosteroid treatment reduced the concentration in nine patients with bronchitis”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A specific radioimmunoassay for carcinoembryonic antigen was used to investigate aspects of its measurement in lung disease.", "patients with chronic obstructive bronchitis", "Corticosteroid treatment reduced the concentration in nine patients with bronchitis", "Corticosteroid treatment reduced the concentration in nine patients with bronchitis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18464226", "title": "[Mycobacterial infection caused by Mycobacterium avium in allogenic bone marrow transplant recipient with concomittant bronchiolitis obliterans as a manifestation of graft versus host disease - case report and review of the literature].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present a case of a female patient after allogenic BMT”; source: title and abstract. Population: No; evidence: “bronchiolitis obliterans as a symptom of graft versus host disease (GvHD)”; source: title and abstract. Intervention or exposure: No; evidence: “treated with corticosteroids”; source: title and abstract. Comparator: No; evidence: “treated with corticosteroids”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We present a case of a female patient after allogenic BMT", "bronchiolitis obliterans as a symptom of graft versus host disease (GvHD)", "treated with corticosteroids", "treated with corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12603799", "title": "Paediatric bronchiectasis in the twenty-first century: experience of a tertiary children's hospital in New Zealand.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A retrospective review of the case histories”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: No; evidence: “Data collected included patient demographics, number of hospitalizations pre- and post-diagnosis, lung function tests, radiology and investigations.”; source: title and abstract. Comparator: No; evidence: “Data collected included patient demographics, number of hospitalizations pre- and post-diagnosis, lung function tests, radiology and investigations.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “bronchiectasis not caused by cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "A retrospective review of the case histories", "Data collected included patient demographics, number of hospitalizations pre- and post-diagnosis, lung function tests, radiology and investigations.", "Data collected included patient demographics, number of hospitalizations pre- and post-diagnosis, lung function tests, radiology and investigations.", "bronchiectasis not caused by cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8745755", "title": "[Bronchiectasis in hemorrhagic rectocolitis. Apropos of a case].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report a case in a 40-year-old patient”; source: title and abstract. Population: Yes; evidence: “Bronchectasis is a rare complication of haemorrhagic rectocolitis”; source: title and abstract. Intervention or exposure: No; evidence: “Local corticosteroids given by inhalation decreased the volume of the expectorations”; source: title and abstract. Comparator: No; evidence: “Local corticosteroids given by inhalation decreased the volume of the expectorations”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report a case in a 40-year-old patient", "Bronchectasis is a rare complication of haemorrhagic rectocolitis", "Local corticosteroids given by inhalation decreased the volume of the expectorations", "Local corticosteroids given by inhalation decreased the volume of the expectorations" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21646806", "title": "An 8-year-old boy with hypereosinophilic syndrome.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present the case of an 8-year-old boy with HES.”; source: title and abstract. Population: No; evidence: “Hypereosinophilic syndrome (HES) is a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia and tissue eosinophilia...”; source: title and abstract. Intervention or exposure: No; evidence: “Only high-dose oral steroid was effective and cyclosporine appeared to have a steroid-sparing effect.”; source: title and abstract. Comparator: No; evidence: “Only high-dose oral steroid was effective and cyclosporine appeared to have a steroid-sparing effect.”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We present the case of an 8-year-old boy with HES.", "Hypereosinophilic syndrome (HES) is a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia and tissue eosinophilia...", "Only high-dose oral steroid was effective and cyclosporine appeared to have a steroid-sparing effect.", "Only high-dose oral steroid was effective and cyclosporine appeared to have a steroid-sparing effect." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19099097", "title": "Determination of the inflammatory component of airway diseases by induced sputum cell counts: use in clinical practice.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We analyzed 151 sputum samples from 132 consecutive patients referred for clinical sputum induction by five pulmonologists between July of 2006 and February of 2007.”; source: title and abstract. Population: Maybe; evidence: “monitoring airway inflammation in patients with bronchiectasis (in 7.3%)”; source: title and abstract. Intervention or exposure: No; evidence: “inhaled corticosteroid dose titration in patients with moderate-to-severe asthma (in 54.3%)”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We analyzed 151 sputum samples from 132 consecutive patients referred for clinical sputum induction by five pulmonologists between July of 2006 and February of 2007.", "monitoring airway inflammation in patients with bronchiectasis (in 7.3%)", "inhaled corticosteroid dose titration in patients with moderate-to-severe asthma (in 54.3%)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18508829", "title": "Adrenal suppression in bronchiectasis and the impact of inhaled corticosteroids.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “In total, 50 outpatients (33 receiving ICSs) underwent a short Synacthen test and completed a St George's Respiratory Questionnaire (SGRQ).”; source: title and abstract. Population: Yes; evidence: “The present study identified three patients with bronchiectasis receiving inhaled corticosteroids (ICSs) who had symptomatic adrenal suppression secondary to ICS.”; source: title and abstract. Intervention or exposure: Yes; evidence: “The present study identified three patients with bronchiectasis receiving inhaled corticosteroids (ICSs) who had symptomatic adrenal suppression secondary to ICS.”; source: title and abstract. Comparator: No; evidence: “In total, 50 outpatients (33 receiving ICSs) underwent a short Synacthen test...”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "In total, 50 outpatients (33 receiving ICSs) underwent a short Synacthen test and completed a St George's Respiratory Questionnaire (SGRQ).", "The present study identified three patients with bronchiectasis receiving inhaled corticosteroids (ICSs) who had symptomatic adrenal suppression secondary to ICS.", "The present study identified three patients with bronchiectasis receiving inhaled corticosteroids (ICSs) who had symptomatic adrenal suppression secondary to ICS.", "In total, 50 outpatients (33 receiving ICSs) underwent a short Synacthen test..." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20304184", "title": "Impact of cytomegalovirus infection in lung transplant patients under universal prophylaxis: single-center experience in Brazil.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Single-center retrospective cohort of LT recipients from August 2003 to March 2008.”; source: title and abstract. Population: No; evidence: “lung transplant (LT) patients”; source: title and abstract. Intervention or exposure: No; evidence: “prophylaxis and surveillance with preemptive treatment is recommended”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Single-center retrospective cohort of LT recipients from August 2003 to March 2008.", "lung transplant (LT) patients", "prophylaxis and surveillance with preemptive treatment is recommended" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17763689", "title": "[A possible case of drug-induced pneumonia due to L-carbocisteine].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 70-year-old man presented with a deteriorating fever and productive cough after the administration of drugs including L-carbocisteine against the common cold.”; source: title and abstract. Population: No; evidence: “chest CT demonstrated pulmonary consolidation with traction bronchiectasis and ground glass opacity with thickened of interlobular septae in the right lung field.”; source: title and abstract. Intervention or exposure: No; evidence: “we halted L-carbocisteine administration stopped and began corticosteroid therapy.”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 70-year-old man presented with a deteriorating fever and productive cough after the administration of drugs including L-carbocisteine against the common cold.", "chest CT demonstrated pulmonary consolidation with traction bronchiectasis and ground glass opacity with thickened of interlobular septae in the right lung field.", "we halted L-carbocisteine administration stopped and began corticosteroid therapy." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19064594", "title": "Comparison of pulmonary CT findings and serum KL-6 levels in patients with cryptogenic organizing pneumonia.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “retrospectively compare high-resolution CT findings”; source: title and abstract. Population: No; evidence: “cryptogenic organizing pneumonia (COP) patients”; source: title and abstract. Intervention or exposure: No; evidence: “initial treatment with steroids”; source: title and abstract. Comparator: No; evidence: “normal and elevated serum KL-6 levels”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “cryptogenic organizing pneumonia (COP) patients”; source: title and abstract.", "evidenceQuotes": [ "retrospectively compare high-resolution CT findings", "cryptogenic organizing pneumonia (COP) patients", "initial treatment with steroids", "normal and elevated serum KL-6 levels", "cryptogenic organizing pneumonia (COP) patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17154672", "title": "Pulmonary involvement in systemic sclerosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “systemic sclerosis”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroids are most effective if given in combination with cyclophosphamide”; source: title and abstract. Comparator: No; evidence: “no strong evidence that any drug alters the course”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “systemic sclerosis”; source: title and abstract.", "evidenceQuotes": [ "systemic sclerosis", "corticosteroids are most effective if given in combination with cyclophosphamide", "no strong evidence that any drug alters the course", "systemic sclerosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21901851", "title": "Autoimmune polyendocrine syndrome type 1: Utility of KCNRG autoantibodies as a marker of active pulmonary disease and successful treatment with rituximab.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We report two patients”; source: title and abstract. Population: No; evidence: “Autoimmune polyendocrine syndrome type 1”; source: title and abstract. Intervention or exposure: No; evidence: “Rituximab treatment was initiated”; source: title and abstract. Comparator: No; evidence: “one with and one without lung disease”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Autoimmune polyendocrine syndrome type 1”; source: title and abstract.", "evidenceQuotes": [ "We report two patients", "Autoimmune polyendocrine syndrome type 1", "Rituximab treatment was initiated", "one with and one without lung disease", "Autoimmune polyendocrine syndrome type 1" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25997166", "title": "Stopping long-acting beta2-agonists (LABA) for children with asthma well controlled on LABA and inhaled corticosteroids.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: Yes; evidence: “parallel randomised controlled trials”; source: title and abstract. Population: No; evidence: “children with asthma”; source: title and abstract. Intervention or exposure: No; evidence: “stepping down to inhaled corticosteroids (ICS)-only therapy versus continuing ICS plus LABA”; source: title and abstract. Comparator: No; evidence: “ICS-only therapy versus continuing ICS plus LABA”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “We excluded studies including participants with other chronic respiratory comorbidities (for example bronchiectasis)”; source: title and abstract.", "evidenceQuotes": [ "parallel randomised controlled trials", "children with asthma", "stepping down to inhaled corticosteroids (ICS)-only therapy versus continuing ICS plus LABA", "ICS-only therapy versus continuing ICS plus LABA", "We excluded studies including participants with other chronic respiratory comorbidities (for example bronchiectasis)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20089343", "title": "[Non-specific interstitial pneumonia with unusual symptoms].", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: Title and abstract are insufficient to determine study design.; source: title and abstract. Population: Maybe; evidence: Title mentions non-specific interstitial pneumonia, not bronchiectasis; abstract unavailable.; source: title and abstract. Intervention or exposure: Maybe; evidence: No information on intervention.; source: title and abstract. Comparator: Maybe; evidence: No information on comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No information on cystic fibrosis.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19386694", "title": "Pseudomonas aeruginosa in patients hospitalised for COPD exacerbation: a prospective study.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We prospectively studied all patients with COPD exacerbation admitted to our hospital between June 2003 and September 2004.”; source: title and abstract. Population: No; evidence: “patients hospitalised for chronic obstructive pulmonary disease (COPD) exacerbation”; source: title and abstract. Intervention or exposure: No; evidence: “systemic steroid treatment”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We prospectively studied all patients with COPD exacerbation admitted to our hospital between June 2003 and September 2004.", "patients hospitalised for chronic obstructive pulmonary disease (COPD) exacerbation", "systemic steroid treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16636525", "title": "Pulse methylprednisolone therapy in type 3 adenovirus pneumonia with hypercytokinemia.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report a case of adenovirus pneumonia”; source: title and abstract. Population: No; evidence: “adenovirus pneumonia”; source: title and abstract. Intervention or exposure: No; evidence: “pulse methylprednisolne therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report a case of adenovirus pneumonia", "adenovirus pneumonia", "pulse methylprednisolne therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22925316", "title": "Long-term macrolide treatment of chronic inflammatory airway diseases: risks, benefits and future developments.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: Maybe; evidence: “chronic inflammatory respiratory diseases, particularly diffuse panbronchiolitis, cystic fibrosis, post-transplant bronchiolitis obliterans and more recently chronic obstructive pulmonary disease (COPD)”; source: title and abstract. Intervention or exposure: No; evidence: “Long-term macrolide treatment”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "chronic inflammatory respiratory diseases, particularly diffuse panbronchiolitis, cystic fibrosis, post-transplant bronchiolitis obliterans and more recently chronic obstructive pulmonary disease (COPD)", "Long-term macrolide treatment", "cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11264756", "title": "Allergic bronchopulmonary aspergillosis: new concepts of pathogenesis and treatment.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “Allergic bronchopulmonary aspergillosis (ABPA)”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroids to suppress eosinophilic airway inflammation”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “Allergic bronchopulmonary aspergillosis is itself an important complication of asthma and cystic fibrosis.”; source: title and abstract.", "evidenceQuotes": [ "Allergic bronchopulmonary aspergillosis (ABPA)", "corticosteroids to suppress eosinophilic airway inflammation", "Allergic bronchopulmonary aspergillosis is itself an important complication of asthma and cystic fibrosis." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8634796", "title": "[Bronchiolitis associated with ulcerative colitis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “we report a case of bronchiolitis”; source: title and abstract. Population: No; evidence: “bronchiolitis in a patient with a prior diagnosis of ulcerative colitis”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid treatment”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "we report a case of bronchiolitis", "bronchiolitis in a patient with a prior diagnosis of ulcerative colitis", "corticosteroid treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24415866", "title": "Pulmonary manifestations of Crohn's disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The treatment of CD-related respiratory disorders depends on the specific pattern of involvement, and in most patients, steroids are required in the initial management.”; source: title and abstract. Population: Maybe; evidence: “The most frequent manifestation is bronchial inflammation and suppuration with or without bronchiectasis.”; source: title and abstract. Intervention or exposure: Maybe; evidence: “steroids are required in the initial management”; source: title and abstract. Comparator: Maybe; evidence: No mention of comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The treatment of CD-related respiratory disorders depends on the specific pattern of involvement, and in most patients, steroids are required in the initial management.", "The most frequent manifestation is bronchial inflammation and suppuration with or without bronchiectasis.", "steroids are required in the initial management" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18846804", "title": "Multiple bronchoceles in a non-asthmatic patient with allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Our patient was a non-asthmatic 18 years old male who presented with chronic cough for 2 years.”; source: title and abstract. Population: Maybe; evidence: “central bronchiectasis (CB) involving main segmental bronchi”; source: title and abstract. Intervention or exposure: No; evidence: “The patient was managed with oral prednisolone”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Our patient was a non-asthmatic 18 years old male who presented with chronic cough for 2 years.", "central bronchiectasis (CB) involving main segmental bronchi", "The patient was managed with oral prednisolone" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11605186", "title": "[A clinical study on patients detected Pasteurella multocida from sputum].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We reported ten cases, (four female and six male), whose sputum cultures positive for Pasteurella multocida from 1990 to 2000.”; source: title and abstract. Population: Maybe; evidence: “inactive lung tuberculosis or bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “P. multocida was almost susceptible to antibioticus (penicillin and cephalosporins)”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We reported ten cases, (four female and six male), whose sputum cultures positive for Pasteurella multocida from 1990 to 2000.", "inactive lung tuberculosis or bronchiectasis", "P. multocida was almost susceptible to antibioticus (penicillin and cephalosporins)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11687146", "title": "Oral steroids for bronchiectasis (stable and acute exacerbations).", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: “Only randomised controlled trials were considered”; source: title and abstract. Population: Yes; evidence: “oral corticosteroids in acute and stable bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “oral corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: No comparator specified in abstract.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Only randomised controlled trials were considered", "oral corticosteroids in acute and stable bronchiectasis", "oral corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20713349", "title": "Iatrogenic osteoporosis, bilateral HIP osteonecrosis, and secondary adrenal suppression in an HIV-infected man receiving inhaled corticosteroids and ritonavir-boosted highly active antiretroviral therapy.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We describe an HIV-infected man with severe osteoporosis, bilateral hip osteonecrosis, and secondary adrenal suppression”; source: title and abstract. Population: Maybe; evidence: “long-standing bronchiectasis treated with inhaled corticosteroids”; source: title and abstract. Intervention or exposure: Yes; evidence: “inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We describe an HIV-infected man with severe osteoporosis, bilateral hip osteonecrosis, and secondary adrenal suppression", "long-standing bronchiectasis treated with inhaled corticosteroids", "inhaled corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8225430", "title": "Effect of steam inhalation on mucociliary activity in patients of chronic pulmonary disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Effect of steam inhalation on mucociliary activity in patients of chronic pulmonary disease.”; source: title and abstract. Population: Maybe; evidence: “patients of chronic pulmonary disease”; source: title and abstract. Intervention or exposure: No; evidence: “steam inhalation”; source: title and abstract. Comparator: Maybe; evidence: “either only bronchodilators, or bronchodilators as well as steroids”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Effect of steam inhalation on mucociliary activity in patients of chronic pulmonary disease.", "patients of chronic pulmonary disease", "steam inhalation", "either only bronchodilators, or bronchodilators as well as steroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8949348", "title": "[Bilateral pneumothorax and hemorrhagic rectocolitis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Case report:”; source: title and abstract. Population: No; evidence: “A 14-year-old girl with ulcerative colitis”; source: title and abstract. Intervention or exposure: No; evidence: “corticoidsteroids and enemas of 5 aminosalicylic acid”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Case report:", "A 14-year-old girl with ulcerative colitis", "corticoidsteroids and enemas of 5 aminosalicylic acid" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12805557", "title": "Thin-section CT in patients with severe acute respiratory syndrome following hospital discharge: preliminary experience.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “patients with severe acute respiratory syndrome (SARS)”; source: title and abstract. Intervention or exposure: No; evidence: “pulsed intravenous methylprednisolone therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "patients with severe acute respiratory syndrome (SARS)", "pulsed intravenous methylprednisolone therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7953501", "title": "Management of allergic bronchopulmonary aspergillosis without maintenance oral corticosteroids: a fifteen-year follow-up.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: Yes; evidence: “All have some localized bronchiectasis on CT scanning”; source: title and abstract. Intervention or exposure: Yes; evidence: “treated since then with inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "All have some localized bronchiectasis on CT scanning", "treated since then with inhaled corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17644942", "title": "[Pulmonary infections in patients with rheumatoid arthritis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We studied 149 rheumatoid arthritis (RA) patients”; source: title and abstract. Population: No; evidence: “rheumatoid arthritis (RA) patients”; source: title and abstract. Intervention or exposure: No; evidence: “therapy with steroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We studied 149 rheumatoid arthritis (RA) patients", "rheumatoid arthritis (RA) patients", "therapy with steroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17035461", "title": "The expanding spectrum of Mycobacterium avium complex-associated pulmonary disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We describe a case of aggressive MAC lung disease in a young immunocompetent female patient”; source: title and abstract. Population: Maybe; evidence: “nodular infiltrates and bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We describe a case of aggressive MAC lung disease in a young immunocompetent female patient", "nodular infiltrates and bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24410485", "title": "Bronchiectasis: an update on current pharmacotherapy and future perspectives.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This review provides an overview”; source: title and abstract. Population: Yes; evidence: “adult patients with idiopathic or post-infection bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: “anti-inflammatory”; source: title and abstract. Comparator: Maybe; evidence: No specific comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This review provides an overview", "adult patients with idiopathic or post-infection bronchiectasis", "anti-inflammatory" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15999563", "title": "[Bronchiectasis--an orphan disease? Diagnosis and treatment in the 21st century].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Lack of sufficient randomized control trials makes it difficult to establish guidelines”; source: title and abstract. Population: Yes; evidence: “Bronchiectasis has been termed an \"orphan disease\"”; source: title and abstract. Intervention or exposure: Maybe; evidence: “inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: No specific comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Lack of sufficient randomized control trials makes it difficult to establish guidelines", "Bronchiectasis has been termed an \"orphan disease\"", "inhaled corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18837683", "title": "Management of bronchiectasis and chronic suppurative lung disease in indigenous children and adults from rural and remote Australian communities.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Consensus recommendations”; source: title and abstract. Population: Yes; evidence: “bronchiectasis in Indigenous children and adults”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Corticosteroids, bronchodilators and mucoactive agents may be used in individual cases”; source: title and abstract. Comparator: Maybe; evidence: No specific comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Consensus recommendations", "bronchiectasis in Indigenous children and adults", "Corticosteroids, bronchodilators and mucoactive agents may be used in individual cases" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "28293347", "title": "[Multiple meningeal and cerebral involvement revealing multifocal tuberculosis in an immunocompetent patient].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report the case of a 30-year old man”; source: title and abstract. Population: No; evidence: “bronchiectasia of the right fowler and culmen”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report the case of a 30-year old man", "bronchiectasia of the right fowler and culmen", "corticosteroid therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10390974", "title": "[Successful treatment of allergic bronchopulmonary aspergillosis with erythromycin and fluconazole].", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “A 30-year-old woman was admitted to our hospital because of productive cough, wheezing, and the disclosure of abnormal shadows on chest X-ray films.”; source: title and abstract. Population: No; evidence: “The patient was given a diagnosis of allergic bronchopulmonary aspergillosis (ABPA) based on eight findings: asthma, eosinophilia, elevated serum IgE concentrations, immediate skin reactivity to Aspergillus antigen, the presence of precipitating antibodies against Aspergillus antigen, lung infiltration, central bronchiectasis, and repeated culture of Aspergillus fumigatus in sputum.”; source: title and abstract. Intervention or exposure: No; evidence: “Because she refused steroids, we administered erythromycin.”; source: title and abstract. Comparator: No; evidence: “Discontinuation of erythromycin resulted in exacerbation of the patient's asthmatic symptoms”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “The patient was given a diagnosis of allergic bronchopulmonary aspergillosis (ABPA)”; source: title and abstract.", "evidenceQuotes": [ "A 30-year-old woman was admitted to our hospital because of productive cough, wheezing, and the disclosure of abnormal shadows on chest X-ray films.", "The patient was given a diagnosis of allergic bronchopulmonary aspergillosis (ABPA) based on eight findings: asthma, eosinophilia, elevated serum IgE concentrations, immediate skin reactivity to Aspergillus antigen, the presence of precipitating antibodies against Aspergillus antigen, lung infiltration, central bronchiectasis, and repeated culture of Aspergillus fumigatus in sputum.", "Because she refused steroids, we administered erythromycin.", "Discontinuation of erythromycin resulted in exacerbation of the patient's asthmatic symptoms", "The patient was given a diagnosis of allergic bronchopulmonary aspergillosis (ABPA)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "14669503", "title": "[Chronic microhematuria with flank pain].", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: Title and abstract are insufficient to determine study design.; source: title and abstract. Population: Maybe; evidence: No information about population.; source: title and abstract. Intervention or exposure: Maybe; evidence: No information about intervention.; source: title and abstract. Comparator: Maybe; evidence: No information about comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No information about cystic fibrosis.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22696672", "title": "Persistent oseltamivir-resistant pandemic influenza A/H1N1 infection in an adult with cystic fibrosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “The authors report the case of a 25-year-old patient with cystic fibrosis (CF)”; source: title and abstract. Population: No; evidence: “The authors report the case of a 25-year-old patient with cystic fibrosis (CF)”; source: title and abstract. Intervention or exposure: No; evidence: “The patient has severe CF lung disease and takes maintenance oral corticosteroids.”; source: title and abstract. Comparator: No; evidence: “The patient has remained sputum-positive for over 4 months despite inhaled zanamivir therapy.”; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “The authors report the case of a 25-year-old patient with cystic fibrosis (CF)”; source: title and abstract.", "evidenceQuotes": [ "The authors report the case of a 25-year-old patient with cystic fibrosis (CF)", "The authors report the case of a 25-year-old patient with cystic fibrosis (CF)", "The patient has severe CF lung disease and takes maintenance oral corticosteroids.", "The patient has remained sputum-positive for over 4 months despite inhaled zanamivir therapy.", "The authors report the case of a 25-year-old patient with cystic fibrosis (CF)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8984918", "title": "Reduced upper airway nitric oxide in cystic fibrosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “In this study, NO concentrations were determined in 63 children with cystic fibrosis, of whom 13 were on inhaled steroids (mean age 13.3 years) and 50 were not (mean age 12.3 years); 57 normal children (mean age 12.2 years) were also studied.”; source: title and abstract. Population: No; evidence: “In this study, NO concentrations were determined in 63 children with cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “of whom 13 were on inhaled steroids”; source: title and abstract. Comparator: No; evidence: “50 were not (mean age 12.3 years)”; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “In this study, NO concentrations were determined in 63 children with cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "In this study, NO concentrations were determined in 63 children with cystic fibrosis, of whom 13 were on inhaled steroids (mean age 13.3 years) and 50 were not (mean age 12.3 years); 57 normal children (mean age 12.2 years) were also studied.", "In this study, NO concentrations were determined in 63 children with cystic fibrosis", "of whom 13 were on inhaled steroids", "50 were not (mean age 12.3 years)", "In this study, NO concentrations were determined in 63 children with cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20146956", "title": "[Nocardia farcinica infection in a patient with cystic fibrosis].", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We report a case of a patient with CF harbouring Nocardia farcinica.”; source: title and abstract. Population: No; evidence: “An 18-year-old male diagnosed with CF at the age of eight”; source: title and abstract. Intervention or exposure: No; evidence: “Treatment with intravenous cotrimoxazole associated with imipenem and amikacin was initiated for three weeks followed by oral cotrimoxazole for a further nine months.”; source: title and abstract. Comparator: No; evidence: “Treatment with intravenous cotrimoxazole associated with imipenem and amikacin was initiated”; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “An 18-year-old male diagnosed with CF at the age of eight”; source: title and abstract.", "evidenceQuotes": [ "We report a case of a patient with CF harbouring Nocardia farcinica.", "An 18-year-old male diagnosed with CF at the age of eight", "Treatment with intravenous cotrimoxazole associated with imipenem and amikacin was initiated for three weeks followed by oral cotrimoxazole for a further nine months.", "Treatment with intravenous cotrimoxazole associated with imipenem and amikacin was initiated", "An 18-year-old male diagnosed with CF at the age of eight" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20673985", "title": "Asthma in the elderly: diagnosis and management.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This review discusses additional specific points for elderly patients.”; source: title and abstract. Population: Maybe; evidence: “Many patients have irreversible airway obstruction, which is due to severe airway remodeling, chronic obstructive pulmonary disease, or bronchiectasis.”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Pharmacologic treatment, too, is adjusted to achieve and maintain control and is basically the same for all ages, except that elderly patients have reduced response to bronchodilators and increased side effects from beta adrenergic agonists and glucocorticoids.”; source: title and abstract. Comparator: Maybe; evidence: No mention of placebo or no medication comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This review discusses additional specific points for elderly patients.", "Many patients have irreversible airway obstruction, which is due to severe airway remodeling, chronic obstructive pulmonary disease, or bronchiectasis.", "Pharmacologic treatment, too, is adjusted to achieve and maintain control and is basically the same for all ages, except that elderly patients have reduced response to bronchodilators and increased side effects from beta adrenergic agonists and glucocorticoids." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8143052", "title": "Outcome of the treatment for sarcoidosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “In a prospective study of patients' with sarcoidosis (n = 98), we limited our use of corticosteroids to those patients who had objective evidence of recent deterioration in lung function or serious extrapulmonary disease.”; source: title and abstract. Population: No; evidence: “The clinical characteristics and pathology of sarcoidosis are well defined; however, the optimal therapy for this disorder remains unclear.”; source: title and abstract. Intervention or exposure: No; evidence: “All patients with sarcoidosis fulfilling these criteria were treated with corticosteroids.”; source: title and abstract. Comparator: Maybe; evidence: “Of the 91 previously untreated patients, 55 were observed without therapy and 36 were treated with corticosteroids.”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "In a prospective study of patients' with sarcoidosis (n = 98), we limited our use of corticosteroids to those patients who had objective evidence of recent deterioration in lung function or serious extrapulmonary disease.", "The clinical characteristics and pathology of sarcoidosis are well defined; however, the optimal therapy for this disorder remains unclear.", "All patients with sarcoidosis fulfilling these criteria were treated with corticosteroids.", "Of the 91 previously untreated patients, 55 were observed without therapy and 36 were treated with corticosteroids." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "14872003", "title": "Immunomodulatory activity and effectiveness of macrolides in chronic airway disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The use of troleandomycin as adjunctive therapy for the treatment of patients with corticosteroid-dependent asthma first suggested an immunomodulatory effect of the macrolide antibiotics.”; source: title and abstract. Population: Maybe; evidence: “Similar benefits have been documented in Japanese studies of bronchiectasis, chronic bronchitis, and sinobronchial syndrome.”; source: title and abstract. Intervention or exposure: No; evidence: “The use of macrolides for the therapy of patients with DPB has led to dramatic improvements in pulmonary function and prolonged survival.”; source: title and abstract. Comparator: Maybe; evidence: No mention of placebo or no medication comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: “Clinical and pathologic similarities between DPB and cystic fibrosis (CF) led to the investigation of macrolides for the treatment of CF.”; source: title and abstract.", "evidenceQuotes": [ "The use of troleandomycin as adjunctive therapy for the treatment of patients with corticosteroid-dependent asthma first suggested an immunomodulatory effect of the macrolide antibiotics.", "Similar benefits have been documented in Japanese studies of bronchiectasis, chronic bronchitis, and sinobronchial syndrome.", "The use of macrolides for the therapy of patients with DPB has led to dramatic improvements in pulmonary function and prolonged survival.", "Clinical and pathologic similarities between DPB and cystic fibrosis (CF) led to the investigation of macrolides for the treatment of CF." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "4800275", "title": "[Inhalation therapy (author's transl)].", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: Title and abstract do not provide study design information.; source: title and abstract. Population: Maybe; evidence: No information about population.; source: title and abstract. Intervention or exposure: Maybe; evidence: No information about intervention.; source: title and abstract. Comparator: Maybe; evidence: No information about comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No information about cystic fibrosis.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9742866", "title": "[Total collapse of the right lung in a patient with allergic bronchopulmonary aspergillosis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 29-year-old man was admitted to the hospital because of a high fever and dyspnea.”; source: title and abstract. Population: No; evidence: “He had a history of bronchial asthma and had had a bullectomy of the right lung at 15 years of age.”; source: title and abstract. Intervention or exposure: No; evidence: “Infusion and inhalation of a corticosteroid and fluconazole were effective”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Allergic bronchopulmonary aspergillosis (ABPA) was diagnosed.”; source: title and abstract.", "evidenceQuotes": [ "A 29-year-old man was admitted to the hospital because of a high fever and dyspnea.", "He had a history of bronchial asthma and had had a bullectomy of the right lung at 15 years of age.", "Infusion and inhalation of a corticosteroid and fluconazole were effective", "Allergic bronchopulmonary aspergillosis (ABPA) was diagnosed." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21867821", "title": "Bronchiectasis: new approaches to diagnosis and management.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Many of the treatment recommendations for non-CF bronchiectasis have not been studied in randomized controlled trials”; source: title and abstract. Population: Yes; evidence: “Non-cystic fibrosis (CF) bronchiectasis is a common, potentially serious, condition.”; source: title and abstract. Intervention or exposure: No; evidence: “Many of the treatment recommendations for non-CF bronchiectasis have not been studied in randomized controlled trials”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Non-cystic fibrosis (CF) bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "Many of the treatment recommendations for non-CF bronchiectasis have not been studied in randomized controlled trials", "Non-cystic fibrosis (CF) bronchiectasis is a common, potentially serious, condition.", "Many of the treatment recommendations for non-CF bronchiectasis have not been studied in randomized controlled trials", "Non-cystic fibrosis (CF) bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "164485", "title": "Bronchorrhoea in a case of alveolar cell carcinoma.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “In a case of bronchorrhoea associated with alveolar cell carcinoma”; source: title and abstract. Population: No; evidence: “alveolar cell carcinoma”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "In a case of bronchorrhoea associated with alveolar cell carcinoma", "alveolar cell carcinoma", "corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12817067", "title": "Current therapeutic possibilities in primary and secondary amyloidosis and our experience with 31 patients.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “we have treated 17 patients with AL and 14 patients with AA amyloidosis since 1995”; source: title and abstract. Population: No; evidence: “Primary (AL) and secondary (AA) amyloidosis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "we have treated 17 patients with AL and 14 patients with AA amyloidosis since 1995", "Primary (AL) and secondary (AA) amyloidosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19099108", "title": "Pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease and bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report the case of a patient”; source: title and abstract. Population: Yes; evidence: “chronic obstructive pulmonary disease and bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “chronically using corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report the case of a patient", "chronic obstructive pulmonary disease and bronchiectasis", "chronically using corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "4007845", "title": "Follicular bronchitis/bronchiolitis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “follicular bronchitis/bronchiolitis”; source: title and abstract. Intervention or exposure: No; evidence: “Steroid therapy had inconsistent effects”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "follicular bronchitis/bronchiolitis", "Steroid therapy had inconsistent effects" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24157860", "title": "Angioimmunoblastic T cell lymphoma: an unusual presentation of posttransplant lymphoproliferative disorder in a pediatric patient.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present an unusual case of monomorphic T cell PTLD with features of angioimmunoblastic T cell lymphoma in an 8-year-old heart transplant patient”; source: title and abstract. Population: No; evidence: “posttransplant lymphoproliferative disorder in a pediatric patient”; source: title and abstract. Intervention or exposure: No; evidence: “immunosuppression in transplant recipients”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We present an unusual case of monomorphic T cell PTLD with features of angioimmunoblastic T cell lymphoma in an 8-year-old heart transplant patient", "posttransplant lymphoproliferative disorder in a pediatric patient", "immunosuppression in transplant recipients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24853025", "title": "Consolidation with a twisted appearance along the airways: a report of five cases of interstitial pneumonia.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “a report of five cases”; source: title and abstract. Population: No; evidence: “five patients with interstitial pneumonia”; source: title and abstract. Intervention or exposure: No; evidence: “steroid administration”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "a report of five cases", "five patients with interstitial pneumonia", "steroid administration" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18023137", "title": "[Refractory asthma: diagnosing allergic bronchopulmonary aspergillosis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Diagnosis in asthma patients is relatively easy; it is based on the association of several criteria”; source: title and abstract. Population: No; evidence: “refractory asthma and cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroids and itraconazole”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "Diagnosis in asthma patients is relatively easy; it is based on the association of several criteria", "refractory asthma and cystic fibrosis", "corticosteroids and itraconazole", "cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19416782", "title": "Severe acute graft versus host disease after lung transplant: report of a case successfully treated with high dose corticosteroids.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “report of a case”; source: title and abstract. Population: No; evidence: “lung transplant”; source: title and abstract. Intervention or exposure: No; evidence: “high-dose corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "report of a case", "lung transplant", "high-dose corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8758507", "title": "[Specific respiratory manifestations associated with hemorrhagic rectocolitis. Analysis of a case and review of the literature].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report a case”; source: title and abstract. Population: No; evidence: “chronic productive bronchitis associated with ulcerative colitis”; source: title and abstract. Intervention or exposure: No; evidence: “steroid efficacy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report a case", "chronic productive bronchitis associated with ulcerative colitis", "steroid efficacy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16801748", "title": "[Guidelines for treatment of pneumonia in intensive care units].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Guidelines for treatment of pneumonia in intensive care units”; source: title and abstract. Population: No; evidence: “Patients affected by pneumonia can be admitted in Intensive Care Units”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “cystic fibrosis, bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "Guidelines for treatment of pneumonia in intensive care units", "Patients affected by pneumonia can be admitted in Intensive Care Units", "cystic fibrosis, bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25871746", "title": "Fatal Hypersensitivity Pneumonitis from Exposure to Fusarium vasinfectum in a Home Environment: A Case Report.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Case report”; source: title and abstract. Population: No; evidence: “A 37-year-old white male presented with a 6-month history of progressively worsening dyspnea, cough, weight loss and fatigue”; source: title and abstract. Intervention or exposure: No; evidence: “Despite aggressive intravenous corticosteroid treatment”; source: title and abstract. Comparator: No; evidence: “Despite aggressive intravenous corticosteroid treatment”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Case report", "A 37-year-old white male presented with a 6-month history of progressively worsening dyspnea, cough, weight loss and fatigue", "Despite aggressive intravenous corticosteroid treatment", "Despite aggressive intravenous corticosteroid treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8379217", "title": "[Aerosol generation and delivery systems for pulmonary drug administration: theory and practice].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Aerosol generation and delivery systems for pulmonary drug administration: theory and practice”; source: title and abstract. Population: No; evidence: “management of asthma and COPD as well as for the treatment of airway and parenchymal infections in bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “inhaled steroids have become the mainstay of therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Aerosol generation and delivery systems for pulmonary drug administration: theory and practice", "management of asthma and COPD as well as for the treatment of airway and parenchymal infections in bronchiectasis", "inhaled steroids have become the mainstay of therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "176747", "title": "Bronchorrhoea.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Bronchorrhoea.”; source: title and abstract. Population: No; evidence: “Bronchorrohea has been defined as a condition in which more than 100 ml of sputum is produced within 24 hours”; source: title and abstract. Intervention or exposure: No; evidence: “Some cases respond to steroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Bronchorrhoea.", "Bronchorrohea has been defined as a condition in which more than 100 ml of sputum is produced within 24 hours", "Some cases respond to steroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9434324", "title": "Endobronchial tuberculosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Endobronchial tuberculosis.”; source: title and abstract. Population: No; evidence: “Endobronchial tuberculosis (EBTB) is a highly infectious disease”; source: title and abstract. Intervention or exposure: No; evidence: “Early treatment with steroid therapy is effective”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Endobronchial tuberculosis.", "Endobronchial tuberculosis (EBTB) is a highly infectious disease", "Early treatment with steroid therapy is effective" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19996746", "title": "Respiratory infection in noncystic fibrosis bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Despite some improvement in the evidence-based guide to management in noncystic fibrosis bronchiectasis, there remains a serious lack of randomized controlled trials directing therapy.”; source: title and abstract. Population: Yes; evidence: “noncystic fibrosis bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: “inhaled corticosteroid cannot be recommended for routine use”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “noncystic fibrosis bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "Despite some improvement in the evidence-based guide to management in noncystic fibrosis bronchiectasis, there remains a serious lack of randomized controlled trials directing therapy.", "noncystic fibrosis bronchiectasis", "inhaled corticosteroid cannot be recommended for routine use", "noncystic fibrosis bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26312591", "title": "Pro-Con Debate: Protracted Bacterial Bronchitis as a Cause of Chronic Cough in Children.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Pro-Con Debate”; source: title and abstract. Population: Maybe; evidence: “children with chronic cough”; source: title and abstract. Intervention or exposure: No; evidence: “inappropriate and excessive use of steroids”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Pro-Con Debate", "children with chronic cough", "inappropriate and excessive use of steroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19838983", "title": "Acute sarcoid myositis with unusual radiologic findings.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 59-year-old man presented”; source: title and abstract. Population: No; evidence: “traction bronchiectases”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid treatment”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 59-year-old man presented", "traction bronchiectases", "corticosteroid treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11896905", "title": "Regression of bilateral bronchiectasis with inhaled steroid therapy.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report the case”; source: title and abstract. Population: Yes; evidence: “idiopathic bilateral bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “inhaled budesonide”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report the case", "idiopathic bilateral bronchiectasis", "inhaled budesonide" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8965405", "title": "[Follicular bronchiolitis associated with rheumatoid arthritis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 52-year-old man”; source: title and abstract. Population: No; evidence: “Follicular bronchiolitis associated with rheumatoid arthritis”; source: title and abstract. Intervention or exposure: No; evidence: “prednisolone therapy”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 52-year-old man", "Follicular bronchiolitis associated with rheumatoid arthritis", "prednisolone therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "3322858", "title": "Management of mucus hypersecretion.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Management of mucus hypersecretion.”; source: title and abstract. Population: Maybe; evidence: “Mucus hypersecretion (greater than 25 ml/day) is commonly seen in chronic bronchitis, whereas bronchorrhea (greater than 100 ml/day) is found in other conditions (e.g. asthma, bronchiectasis, alveolar-cell carcinoma).”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Corticosteroids are effective in bronchorrhoea and asthma.”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Management of mucus hypersecretion.", "Mucus hypersecretion (greater than 25 ml/day) is commonly seen in chronic bronchitis, whereas bronchorrhea (greater than 100 ml/day) is found in other conditions (e.g. asthma, bronchiectasis, alveolar-cell carcinoma).", "Corticosteroids are effective in bronchorrhoea and asthma." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26558756", "title": "A Retrospective Longitudinal Within-Subject Risk Interval Analysis of Immunoglobulin Treatment for Recurrent Acute Exacerbation of Chronic Obstructive Pulmonary Disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A Retrospective Longitudinal Within-Subject Risk Interval Analysis”; source: title and abstract. Population: Maybe; evidence: “Eight had CT radiographic bronchiectasis.”; source: title and abstract. Intervention or exposure: No; evidence: “immunoglobulin (Ig) treatment as adjunctive preventative treatment for AECOPD”; source: title and abstract. Comparator: No; evidence: “before and after initiation of Ig treatment”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A Retrospective Longitudinal Within-Subject Risk Interval Analysis", "Eight had CT radiographic bronchiectasis.", "immunoglobulin (Ig) treatment as adjunctive preventative treatment for AECOPD", "before and after initiation of Ig treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25135408", "title": "[Coronary artery bypass grafting in a patient with chronic bird fancier's lung].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report an 80-year-old man”; source: title and abstract. Population: No; evidence: “chronic bird fancier's lung”; source: title and abstract. Intervention or exposure: No; evidence: “Immediate steroid pulse therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report an 80-year-old man", "chronic bird fancier's lung", "Immediate steroid pulse therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25583961", "title": "Nocardia cyriacigeorgica in an immunocompetent patient.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Nocardia cyriacigeorgica in an immunocompetent patient.”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Nocardia cyriacigeorgica in an immunocompetent patient." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11124647", "title": "Exhaled nitric oxide--is it really a good marker of airway inflammation in bronchial asthma?", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Exhaled [NO] was measured in patients with bronchial asthma (43 steroid treated and 32 steroid naive), chronic obstructive pulmonary disease (COPD) (n = 36), bronchiectasis (n = 10) and in control subjects (n = 26).”; source: title and abstract. Population: Maybe; evidence: “bronchiectasis (n = 10)”; source: title and abstract. Intervention or exposure: No; evidence: “receiving inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Exhaled [NO] was measured in patients with bronchial asthma (43 steroid treated and 32 steroid naive), chronic obstructive pulmonary disease (COPD) (n = 36), bronchiectasis (n = 10) and in control subjects (n = 26).", "bronchiectasis (n = 10)", "receiving inhaled corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8984919", "title": "Exhaled nitric oxide in paediatric asthma and cystic fibrosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “NO excretion was measured in the nasal cavity and in orally exhaled air in 19 healthy children, in 36 age matched subjects with asthma, and in eight children with cystic fibrosis.”; source: title and abstract. Population: No; evidence: “children with cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “NO excretion was measured”; source: title and abstract. Comparator: No; evidence: “NO levels in orally exhaled air were similar in controls and in children with cystic fibrosis”; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “children with cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "NO excretion was measured in the nasal cavity and in orally exhaled air in 19 healthy children, in 36 age matched subjects with asthma, and in eight children with cystic fibrosis.", "children with cystic fibrosis", "NO excretion was measured", "NO levels in orally exhaled air were similar in controls and in children with cystic fibrosis", "children with cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24124045", "title": "Treatment and outcomes of chronic rhinosinusitis in children with primary ciliary dyskinesia: where is the evidence? A qualitative systematic review.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This work is a systematic review”; source: title and abstract. Population: No; evidence: “children with primary ciliary dyskinesia (PCD)”; source: title and abstract. Intervention or exposure: No; evidence: “Medical treatment included oral antibiotics, intranasal steroids, and oral steroids.”; source: title and abstract. Comparator: No; evidence: “No randomized, controlled, or long-term prospective cohort studies were identified”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This work is a systematic review", "children with primary ciliary dyskinesia (PCD)", "Medical treatment included oral antibiotics, intranasal steroids, and oral steroids.", "No randomized, controlled, or long-term prospective cohort studies were identified" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19058490", "title": "[Allergic bronchopulmonary aspergillosis. A report of a case and literature review].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present the case of a 3-year-old boy”; source: title and abstract. Population: No; evidence: “without bronchiectasies”; source: title and abstract. Intervention or exposure: No; evidence: “We treated him with step approach of ICS according to GINA 2006”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We present the case of a 3-year-old boy", "without bronchiectasies", "We treated him with step approach of ICS according to GINA 2006" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7716312", "title": "[Signs of inflammatory activity in thoracic sarcoidosis. A high-resolution computerized tomography study].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Sixty-three patients underwent chest radiography, high resolution CT, functional studies, bronchoalveolar lavage and 67Ga scintigraphy.”; source: title and abstract. Population: No; evidence: “thoracic sarcoidosis”; source: title and abstract. Intervention or exposure: No; evidence: “resolved after steroid therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Sixty-three patients underwent chest radiography, high resolution CT, functional studies, bronchoalveolar lavage and 67Ga scintigraphy.", "thoracic sarcoidosis", "resolved after steroid therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8428430", "title": "Allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The history, clinical features, diagnosis, treatment, and monitoring of allergic bronchopulmonary aspergillosis (ABPA) are described.”; source: title and abstract. Population: No; evidence: “patients with asthma and cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “The most effective treatment for ABPA is oral prednisone”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “patients with asthma and cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "The history, clinical features, diagnosis, treatment, and monitoring of allergic bronchopulmonary aspergillosis (ABPA) are described.", "patients with asthma and cystic fibrosis", "The most effective treatment for ABPA is oral prednisone", "patients with asthma and cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16473820", "title": "Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients.”; source: title and abstract. Population: No; evidence: “Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients.”; source: title and abstract. Intervention or exposure: No; evidence: “Treatment consists of long-term systemic corticosteroid usage”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned in the abstract.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients.”; source: title and abstract.", "evidenceQuotes": [ "Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients.", "Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients.", "Treatment consists of long-term systemic corticosteroid usage", "Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "28050004", "title": "Interstitial Lung Disease Induced by Pazopanib Treatment.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 74-year-old Japanese man who received pazopanib for the treatment of femoral leiomyosarcoma and lung metastasis presented with dyspnea and fatigue.”; source: title and abstract. Population: No; evidence: “He had mild interstitial pneumonia when pazopanib treatment was initiated. Chest computed tomography revealed progressive bilateral ground-glass opacity (GGO) and traction bronchiectasis.”; source: title and abstract. Intervention or exposure: No; evidence: “pazopanib treatment”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 74-year-old Japanese man who received pazopanib for the treatment of femoral leiomyosarcoma and lung metastasis presented with dyspnea and fatigue.", "He had mild interstitial pneumonia when pazopanib treatment was initiated. Chest computed tomography revealed progressive bilateral ground-glass opacity (GGO) and traction bronchiectasis.", "pazopanib treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11734464", "title": "Remodeling in asthma and chronic obstructive lung disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The following synopsis defines and compares the key remodeling processes and proposes several hypotheses.”; source: title and abstract. Population: No; evidence: “Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung”; source: title and abstract. Intervention or exposure: No; evidence: “The number of bronchial vessels and the area of the wall occupied by them increase in severe corticosteroid-dependent asthma”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The following synopsis defines and compares the key remodeling processes and proposes several hypotheses.", "Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung", "The number of bronchial vessels and the area of the wall occupied by them increase in severe corticosteroid-dependent asthma" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9742863", "title": "[Diffuse panbronchiolitis with myeloperoxidase-specific antineutrophil cytoplasmic antibody-related vasculitis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 46-year-old woman was referred to our department in July 1996 with complaints of fever and myalgia in her calves.”; source: title and abstract. Population: No; evidence: “diffuse panbronchiolitis had been diagnosed in 1983”; source: title and abstract. Intervention or exposure: No; evidence: “She was treated with 1 g of methylprednisolone daily for 3 days, followed by 60 mg of prednisolone and 50 mg of cyclophosphamide daily.”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 46-year-old woman was referred to our department in July 1996 with complaints of fever and myalgia in her calves.", "diffuse panbronchiolitis had been diagnosed in 1983", "She was treated with 1 g of methylprednisolone daily for 3 days, followed by 60 mg of prednisolone and 50 mg of cyclophosphamide daily." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21300218", "title": "[Hot topics in respiratory infections].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We review the most interesting articles on respiratory infections published in the last trimester of 2009 and in 2010.”; source: title and abstract. Population: Maybe; evidence: “Notable publications in bronchiectasis were the Guidelines of the British Thoracic Society, as well as several articles on the natural course of the process, the impact of exacerbations on the course of the disease, and treatment with inhaled antibiotics.”; source: title and abstract. Intervention or exposure: No; evidence: “treatment with inhaled antibiotics”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We review the most interesting articles on respiratory infections published in the last trimester of 2009 and in 2010.", "Notable publications in bronchiectasis were the Guidelines of the British Thoracic Society, as well as several articles on the natural course of the process, the impact of exacerbations on the course of the disease, and treatment with inhaled antibiotics.", "treatment with inhaled antibiotics" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16128227", "title": "Pulmonary involvement in systemic sclerosis due to therapy and as a complication.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We report a case of a patient affected by SS”; source: title and abstract. Population: No; evidence: “systemic sclerosis (SS)”; source: title and abstract. Intervention or exposure: No; evidence: “without increasing the steroids”; source: title and abstract. Comparator: No; evidence: “without increasing the steroids”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “systemic sclerosis (SS)”; source: title and abstract.", "evidenceQuotes": [ "We report a case of a patient affected by SS", "systemic sclerosis (SS)", "without increasing the steroids", "without increasing the steroids", "systemic sclerosis (SS)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15206498", "title": "Subjective benefit of inhaled therapies in patients with bronchiectasis: a questionnaire study.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “questionnaire study”; source: title and abstract. Population: Yes; evidence: “patients with bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: “inhaled therapies”; source: title and abstract. Comparator: Maybe; evidence: “subjective benefits”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “patients with bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "questionnaire study", "patients with bronchiectasis", "inhaled therapies", "subjective benefits", "patients with bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22855546", "title": "Pseudobronchiectasis after pertussis and mycoplasma infection.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Pseudobronchiectasis after pertussis and mycoplasma infection”; source: title and abstract. Population: Maybe; evidence: “Pseudobronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Pseudobronchiectasis after pertussis and mycoplasma infection", "Pseudobronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10073280", "title": "Allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Allergic bronchopulmonary aspergillosis”; source: title and abstract. Population: No; evidence: “patients with asthma and cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “oral corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “patients with asthma and cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "Allergic bronchopulmonary aspergillosis", "patients with asthma and cystic fibrosis", "oral corticosteroids", "patients with asthma and cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "27329097", "title": "Laryngeal leishmaniasis in a patient taking inhaled corticosteroids.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present a case of a man”; source: title and abstract. Population: Yes; evidence: “background of asthma and bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “taking inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “background of asthma and bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "We present a case of a man", "background of asthma and bronchiectasis", "taking inhaled corticosteroids", "background of asthma and bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20159270", "title": "When oral corticosteroids are essential for persistent severe asthma.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “When oral corticosteroids are essential for persistent severe asthma.”; source: title and abstract. Population: No; evidence: “persistent severe asthma”; source: title and abstract. Intervention or exposure: No; evidence: “oral corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “persistent severe asthma”; source: title and abstract.", "evidenceQuotes": [ "When oral corticosteroids are essential for persistent severe asthma.", "persistent severe asthma", "oral corticosteroids", "persistent severe asthma" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7088769", "title": "[Bronchopulmonary aspergillosis (author's transl)].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Bronchopulmonary aspergillosis (author's transl)”; source: title and abstract. Population: No; evidence: “Bronchopulmonary infections with Aspergillus”; source: title and abstract. Intervention or exposure: No; evidence: “corticotherapy”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Bronchopulmonary infections with Aspergillus”; source: title and abstract.", "evidenceQuotes": [ "Bronchopulmonary aspergillosis (author's transl)", "Bronchopulmonary infections with Aspergillus", "corticotherapy", "Bronchopulmonary infections with Aspergillus" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17488142", "title": "Is there a role for inhaled corticosteroids and macrolide therapy in bronchiectasis?", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This article reviews the anti-inflammatory properties, clinical efficacy and adverse effects of ICS and macrolides.”; source: title and abstract. Population: Yes; evidence: “Bronchiectasis is characterised by permanent dilatation of the bronchi”; source: title and abstract. Intervention or exposure: Yes; evidence: “inhaled corticosteroids (ICS)”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Bronchiectasis is characterised by permanent dilatation of the bronchi”; source: title and abstract.", "evidenceQuotes": [ "This article reviews the anti-inflammatory properties, clinical efficacy and adverse effects of ICS and macrolides.", "Bronchiectasis is characterised by permanent dilatation of the bronchi", "inhaled corticosteroids (ICS)", "Bronchiectasis is characterised by permanent dilatation of the bronchi" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15741443", "title": "Inhaled fluticasone in bronchiectasis: a 12 month study.", "abstractAvailable": true, "decision": "include", "recommendation": "include", "confidence": "high", "rationale": "Title-and-abstract screening: retain for the next stage. Study design: Yes; evidence: “86 patients were randomised to receive either fluticasone 500 mug twice daily (n = 43, 23F, mean (SD) age 57.7 (14.4) years) or matched placebo (n = 43, 34F, 59.2 (14.2) years) and reviewed regularly for 52 weeks in a double blind fashion.”; source: title and abstract. Population: Yes; evidence: “Inhaled fluticasone in bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “fluticasone 500 mug twice daily”; source: title and abstract. Comparator: Yes; evidence: “matched placebo”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Inhaled fluticasone in bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "86 patients were randomised to receive either fluticasone 500 mug twice daily (n = 43, 23F, mean (SD) age 57.7 (14.4) years) or matched placebo (n = 43, 34F, 59.2 (14.2) years) and reviewed regularly for 52 weeks in a double blind fashion.", "Inhaled fluticasone in bronchiectasis", "fluticasone 500 mug twice daily", "matched placebo", "Inhaled fluticasone in bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24199804", "title": "Allergic bronchopulmonary aspergillosis in asthma: epidemiological, clinical and therapeutic issues.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Allergic bronchopulmonary aspergillosis in asthma: epidemiological, clinical and therapeutic issues.”; source: title and abstract. Population: No; evidence: “asthmatic patients”; source: title and abstract. Intervention or exposure: No; evidence: “Glucocorticoids are the treatment of choice”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “asthmatic patients”; source: title and abstract.", "evidenceQuotes": [ "Allergic bronchopulmonary aspergillosis in asthma: epidemiological, clinical and therapeutic issues.", "asthmatic patients", "Glucocorticoids are the treatment of choice", "asthmatic patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24131836", "title": "[Clinical analysis of 28 cases of bronchiolitis obliterans].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The clinical data of 28 children with BO between July 2007 and April 2012 was retrospectively reviewed.”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: No; evidence: “All 28 cases received corticosteroid treatment”; source: title and abstract. Comparator: No; evidence: “All 28 cases received corticosteroid treatment”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The clinical data of 28 children with BO between July 2007 and April 2012 was retrospectively reviewed.", "All 28 cases received corticosteroid treatment", "All 28 cases received corticosteroid treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10094224", "title": "Thorax high resolution computerized tomography findings in asthmatic children with unusual clinical manifestations.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “asthmatic children”; source: title and abstract. Intervention or exposure: No; evidence: “inhaled steroid therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "asthmatic children", "inhaled steroid therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1470715", "title": "Sputum production in bronchiectasis treated with inhaled beclomethasone.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: Title suggests a treatment study but abstract is missing; cannot determine design.; source: title and abstract. Population: Yes; evidence: “Sputum production in bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “inhaled beclomethasone”; source: title and abstract. Comparator: Maybe; evidence: Abstract missing; comparator unknown.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Sputum production in bronchiectasis", "inhaled beclomethasone" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22167396", "title": "Allergic bronchopulmonary aspergillosis and related allergic syndromes.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “While allergic bronchopulmonary aspergillosis (ABPA) is well recognized ...”; source: title and abstract. Population: No; evidence: “ABPA may present with any severity of asthma, and occasionally with no asthma or cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “both ABPA and SAFS respond to both high doses of corticosteroids and oral antifungal agents”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “occasionally with no asthma or cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "While allergic bronchopulmonary aspergillosis (ABPA) is well recognized ...", "ABPA may present with any severity of asthma, and occasionally with no asthma or cystic fibrosis", "both ABPA and SAFS respond to both high doses of corticosteroids and oral antifungal agents", "occasionally with no asthma or cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18041077", "title": "Chronic lung disease in human immunodeficiency virus (HIV) infected children.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The development of chronic lung disease is common in HIV-infected children.”; source: title and abstract. Population: No; evidence: “HIV-infected children”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroids for children with LIP”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The development of chronic lung disease is common in HIV-infected children.", "HIV-infected children", "corticosteroids for children with LIP" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1793341", "title": "[Mucoviscidosis and allergic bronchopulmonary aspergillosis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Allergic bronchopulmonary aspergillosis (ABPA) is a severe disease inducing bronchopulmonary anatomic lesions which complicate those already present in patients with cystic fibrosis.”; source: title and abstract. Population: No; evidence: “patients with cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “oral corticosteroid treatment is the only one able to prevent evolution towards bronchiectasies”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “patients with cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "Allergic bronchopulmonary aspergillosis (ABPA) is a severe disease inducing bronchopulmonary anatomic lesions which complicate those already present in patients with cystic fibrosis.", "patients with cystic fibrosis", "oral corticosteroid treatment is the only one able to prevent evolution towards bronchiectasies", "patients with cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "5562607", "title": "[Medical treatment of chronic bronchitis and bronchiectasis].", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: No abstract available; cannot determine study design.; source: title and abstract. Population: Maybe; evidence: Title mentions chronic bronchitis and bronchiectasis, but no details on CF status.; source: title and abstract. Intervention or exposure: Maybe; evidence: Title mentions medical treatment but not specifically inhaled corticosteroids.; source: title and abstract. Comparator: Maybe; evidence: No information on comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No information on CF exclusion.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23137883", "title": "Pulmonary manifestations of anti-ARS antibody positive interstitial pneumonia--with or without PM/DM.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We retrospectively examined 36 IP patients with anti-ARS antibodies.”; source: title and abstract. Population: No; evidence: “anti-ARS antibody-positive IP patients”; source: title and abstract. Intervention or exposure: No; evidence: “initial corticosteroid or immunosuppressant therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We retrospectively examined 36 IP patients with anti-ARS antibodies.", "anti-ARS antibody-positive IP patients", "initial corticosteroid or immunosuppressant therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26204816", "title": "New treatment strategies for pulmonary sarcoidosis: antimetabolites, biological drugs, and other treatment approaches.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We propose a step-wise approach to the management of pulmonary disease in sarcoidosis”; source: title and abstract. Population: No; evidence: “patients with sarcoidosis”; source: title and abstract. Intervention or exposure: No; evidence: “Oral glucocorticoids are the standard first-line treatment”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We propose a step-wise approach to the management of pulmonary disease in sarcoidosis", "patients with sarcoidosis", "Oral glucocorticoids are the standard first-line treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "4391429", "title": "[Therapeutic results in chronic obstructive lung diseases].", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: No abstract available; cannot determine study design.; source: title and abstract. Population: Maybe; evidence: Title mentions chronic obstructive lung diseases, which may include bronchiectasis but not specific.; source: title and abstract. Intervention or exposure: Maybe; evidence: No information on intervention.; source: title and abstract. Comparator: Maybe; evidence: No information on comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No information on CF exclusion.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "28065254", "title": "Pulmonary Eosinophilia From Inhaled Colistin.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report the case of a patient”; source: title and abstract. Population: Yes; evidence: “a patient with a history of chronic bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report the case of a patient", "a patient with a history of chronic bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12477240", "title": "Bronchiectasis in a patient with CREST syndrome.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report the case”; source: title and abstract. Population: Yes; evidence: “developed multifocal symptomatic bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “immunosuppressive therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report the case", "developed multifocal symptomatic bronchiectasis", "immunosuppressive therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1519835", "title": "Sputum ECP levels correlate with parameters of airflow obstruction.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “concentrations of serum and sputum eosinophil cationic protein (ECP) from 134 patients”; source: title and abstract. Population: Maybe; evidence: “patients with productive cough and a history suggestive of airflow obstruction”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid treatment influences sputum ECP levels”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: “one cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "concentrations of serum and sputum eosinophil cationic protein (ECP) from 134 patients", "patients with productive cough and a history suggestive of airflow obstruction", "corticosteroid treatment influences sputum ECP levels", "one cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15302742", "title": "C-reactive protein and body mass index predict outcome in end-stage respiratory failure.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Prospective, multicenter cohort study”; source: title and abstract. Population: Maybe; evidence: Mixed population; only 7.4% have bronchiectasis, not exclusively stable bronchiectasis without CF.; source: title and abstract. Intervention or exposure: No; evidence: “oral corticosteroid use”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No mention of cystic fibrosis; unclear if excluded.; source: title and abstract.", "evidenceQuotes": [ "Prospective, multicenter cohort study", "oral corticosteroid use" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21772668", "title": "Malondialdehyde in exhaled breath condensate as a marker of oxidative stress in different pulmonary diseases.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We measured MDA levels in EBC in a large number of patients”; source: title and abstract. Population: Maybe; evidence: Includes bronchiectasis but also other diseases; not exclusively stable bronchiectasis without CF.; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroids-treated subjects”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No mention of cystic fibrosis; unclear if excluded.; source: title and abstract.", "evidenceQuotes": [ "We measured MDA levels in EBC in a large number of patients", "corticosteroids-treated subjects" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10998853", "title": "Chronic eosinophilic pneumonia: a case report.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We describe a 28-year-old woman who presented with cough, dyspnea and fever for 2 months.”; source: title and abstract. Population: No; evidence: “A computerized tomography of the chest did not show bronchiectasis.”; source: title and abstract. Intervention or exposure: No; evidence: “The patient was treated with prednisolone 45 mg/day.”; source: title and abstract. Comparator: No; evidence: “The patient was treated with prednisolone 45 mg/day.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “without any organic causes”; source: title and abstract.", "evidenceQuotes": [ "We describe a 28-year-old woman who presented with cough, dyspnea and fever for 2 months.", "A computerized tomography of the chest did not show bronchiectasis.", "The patient was treated with prednisolone 45 mg/day.", "The patient was treated with prednisolone 45 mg/day.", "without any organic causes" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24717623", "title": "Opportunities to diagnose chronic obstructive pulmonary disease in routine care in the UK: a retrospective study of a clinical cohort.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We did a retrospective analysis of a clinical cohort”; source: title and abstract. Population: No; evidence: “patients aged 40 years or older who had an electronically coded diagnosis of COPD”; source: title and abstract. Intervention or exposure: No; evidence: “We assessed patterns of health-care use”; source: title and abstract. Comparator: No; evidence: “We assessed patterns of health-care use”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We did a retrospective analysis of a clinical cohort", "patients aged 40 years or older who had an electronically coded diagnosis of COPD", "We assessed patterns of health-care use", "We assessed patterns of health-care use" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "423017", "title": "Allergic bronchopulmonary aspergillosis in pediatric practice.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Twelve cases of allergic bronchopulmonary aspergillosis in the pediatric age group are reported.”; source: title and abstract. Population: No; evidence: “All patients had a history of pulmonary infiltrations or atelectasis or both documented by chest radiographs. Eight patients had bronchograms or tomograms, and seven of them showed proximal bronchiectasis.”; source: title and abstract. Intervention or exposure: No; evidence: “After prednisone was started”; source: title and abstract. Comparator: No; evidence: “After prednisone was started”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Allergic bronchopulmonary aspergillosis”; source: title and abstract.", "evidenceQuotes": [ "Twelve cases of allergic bronchopulmonary aspergillosis in the pediatric age group are reported.", "All patients had a history of pulmonary infiltrations or atelectasis or both documented by chest radiographs. Eight patients had bronchograms or tomograms, and seven of them showed proximal bronchiectasis.", "After prednisone was started", "After prednisone was started", "Allergic bronchopulmonary aspergillosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "324510", "title": "Asthmatic pulmonary eosinophilia: a review of 65 cases.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “In a series of 65 patients with asthma with pulmonary eosinophilia”; source: title and abstract. Population: No; evidence: “asthma with pulmonary eosinophilia”; source: title and abstract. Intervention or exposure: No; evidence: “Those patients who received long-term daily corticosteroid therapy”; source: title and abstract. Comparator: No; evidence: “Those patients who received long-term daily corticosteroid therapy were less likely to develop further radiographic opacities than those given intermittent corticosteroid therapy.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “asthma with pulmonary eosinophilia”; source: title and abstract.", "evidenceQuotes": [ "In a series of 65 patients with asthma with pulmonary eosinophilia", "asthma with pulmonary eosinophilia", "Those patients who received long-term daily corticosteroid therapy", "Those patients who received long-term daily corticosteroid therapy were less likely to develop further radiographic opacities than those given intermittent corticosteroid therapy.", "asthma with pulmonary eosinophilia" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25710129", "title": "Post-infectious bronchiolitis obliterans in children: CT features that predict responsiveness to pulse methylprednisolone.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We searched the medical records for patients (less than 18 years of age) who were diagnosed with post-infectious OB between January 2000 and December 2011. 17 children who received IPMT were included in this study.”; source: title and abstract. Population: No; evidence: “post-infectious obliterative bronchiolitis”; source: title and abstract. Intervention or exposure: No; evidence: “Intravenous pulse methylprednisolone therapy (IPMT)”; source: title and abstract. Comparator: No; evidence: “The nine patients who exhibited decreased air trapping on post-treatment CT scans relative to pre-treatment scans were classed as responders.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “post-infectious OB”; source: title and abstract.", "evidenceQuotes": [ "We searched the medical records for patients (less than 18 years of age) who were diagnosed with post-infectious OB between January 2000 and December 2011. 17 children who received IPMT were included in this study.", "post-infectious obliterative bronchiolitis", "Intravenous pulse methylprednisolone therapy (IPMT)", "The nine patients who exhibited decreased air trapping on post-treatment CT scans relative to pre-treatment scans were classed as responders.", "post-infectious OB" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1198394", "title": "Effect of atropine on sputum production.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The effect of atropine on sputum production has been studied in patients with asthama, chronic bronchitis, and bronchiectasis”; source: title and abstract. Population: Yes; evidence: “patients with asthama, chronic bronchitis, and bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “The effect of atropine on sputum production”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned in the abstract.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “patients with asthama, chronic bronchitis, and bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "The effect of atropine on sputum production has been studied in patients with asthama, chronic bronchitis, and bronchiectasis", "patients with asthama, chronic bronchitis, and bronchiectasis", "The effect of atropine on sputum production", "patients with asthama, chronic bronchitis, and bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12038874", "title": "Treatment of severe small airways disease in children with cystic fibrosis: alternatives to corticosteroids.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Therapeutic alternatives to corticosteroids are aimed at reversing bronchoconstriction and reducing inflammation.”; source: title and abstract. Population: No; evidence: “A group of patients with cystic fibrosis (CF) have severe small airways disease”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Inhaled corticosteroids are used in many centers despite the lack of conclusive evidence of their efficacy.”; source: title and abstract. Comparator: Maybe; evidence: No comparator is specified.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “A group of patients with cystic fibrosis (CF)”; source: title and abstract.", "evidenceQuotes": [ "Therapeutic alternatives to corticosteroids are aimed at reversing bronchoconstriction and reducing inflammation.", "A group of patients with cystic fibrosis (CF) have severe small airways disease", "Inhaled corticosteroids are used in many centers despite the lack of conclusive evidence of their efficacy.", "A group of patients with cystic fibrosis (CF)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24433801", "title": "[Allergic bronchopulmonary aspergillosis in patients with chronic obstructive pulmonary disease: report of 3 cases].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We retrospectively analyzed the clinical information of 3 cases”; source: title and abstract. Population: Yes; evidence: “allergic bronchopulmonary aspergillosis (ABPA) combined with COPD”; source: title and abstract. Intervention or exposure: No; evidence: “the patients were all given oral prednisone therapy”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “COPD patients”; source: title and abstract.", "evidenceQuotes": [ "We retrospectively analyzed the clinical information of 3 cases", "allergic bronchopulmonary aspergillosis (ABPA) combined with COPD", "the patients were all given oral prednisone therapy", "COPD patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15977917", "title": "Antiinflammatory therapies for cystic fibrosis: past, present, and future.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Antiinflammatory therapies for cystic fibrosis: past, present, and future.”; source: title and abstract. Population: No; evidence: “cystic fibrosis pulmonary disease”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Inhaled corticosteroids, colchicine, methotrexate, montelukast, pentoxifylline, nutritional supplements, and protease replacement have not had a significant impact on the disease.”; source: title and abstract. Comparator: Maybe; evidence: No comparator is specified.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “cystic fibrosis pulmonary disease”; source: title and abstract.", "evidenceQuotes": [ "Antiinflammatory therapies for cystic fibrosis: past, present, and future.", "cystic fibrosis pulmonary disease", "Inhaled corticosteroids, colchicine, methotrexate, montelukast, pentoxifylline, nutritional supplements, and protease replacement have not had a significant impact on the disease.", "cystic fibrosis pulmonary disease" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26171905", "title": "Interventions for bronchiectasis: an overview of Cochrane systematic reviews.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “an overview of Cochrane systematic reviews”; source: title and abstract. Population: Yes; evidence: “non-cystic fibrosis (CF) bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Improvements in lung function were reported for inhaled corticosteroids (ICS)”; source: title and abstract. Comparator: Maybe; evidence: No comparator is specified.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non-cystic fibrosis (CF) bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "an overview of Cochrane systematic reviews", "non-cystic fibrosis (CF) bronchiectasis", "Improvements in lung function were reported for inhaled corticosteroids (ICS)", "non-cystic fibrosis (CF) bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19996193", "title": "Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Patients with RA-ILD were identified retrospectively (n = 82).”; source: title and abstract. Population: No; evidence: “rheumatoid arthritis-associated interstitial lung disease”; source: title and abstract. Intervention or exposure: No; evidence: “The relationship of a definite usual interstitial pneumonia pattern on HRCT to survival was determined”; source: title and abstract. Comparator: No; evidence: “compared to that in a cohort of patients with radiologically diagnosed idiopathic pulmonary fibrosis”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “rheumatoid arthritis-associated interstitial lung disease”; source: title and abstract.", "evidenceQuotes": [ "Patients with RA-ILD were identified retrospectively (n = 82).", "rheumatoid arthritis-associated interstitial lung disease", "The relationship of a definite usual interstitial pneumonia pattern on HRCT to survival was determined", "compared to that in a cohort of patients with radiologically diagnosed idiopathic pulmonary fibrosis", "rheumatoid arthritis-associated interstitial lung disease" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11345841", "title": "Diffuse pulmonary disease caused by nontuberculous mycobacteria in immunocompetent people (hot tub lung).", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report a less well-described manifestation of NTM infection: 10 immunocompetent patients”; source: title and abstract. Population: No; evidence: “without preexisting bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “Four patients received corticosteroids alone for presumed hypersensitivity pneumonia, 4 were treated with antimycobacterial therapy, and 2 received both.”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “immunocompetent patients”; source: title and abstract.", "evidenceQuotes": [ "We report a less well-described manifestation of NTM infection: 10 immunocompetent patients", "without preexisting bronchiectasis", "Four patients received corticosteroids alone for presumed hypersensitivity pneumonia, 4 were treated with antimycobacterial therapy, and 2 received both.", "immunocompetent patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "3971757", "title": "Roentgenographic and clinical staging of allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We studied 24 ABPA patients actively followed for up to 11 years at our institution.”; source: title and abstract. Population: No; evidence: “Allergic bronchopulmonary aspergillosis (ABPA) is a disease of asthmatics”; source: title and abstract. Intervention or exposure: No; evidence: “When ABPA is treated with high dose corticosteroids”; source: title and abstract. Comparator: No; evidence: “Five stages, based on clinical, roentgenographic, and immunologic criteria, have been identified”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “asthmatics”; source: title and abstract.", "evidenceQuotes": [ "We studied 24 ABPA patients actively followed for up to 11 years at our institution.", "Allergic bronchopulmonary aspergillosis (ABPA) is a disease of asthmatics", "When ABPA is treated with high dose corticosteroids", "Five stages, based on clinical, roentgenographic, and immunologic criteria, have been identified", "asthmatics" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24971644", "title": "Primary vs. secondary antibody deficiency: clinical features and infection outcomes of immunoglobulin replacement.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “The demographics, causes of immunodeficiency, diagnostic delay, clinical and laboratory features, and infection frequency were analysed retrospectively.”; source: title and abstract. Population: No; evidence: “primary or secondary antibody deficiencies”; source: title and abstract. Intervention or exposure: No; evidence: “immunoglobulin (Ig)-replacement treatment”; source: title and abstract. Comparator: No; evidence: “infection outcomes of immunoglobulin replacement”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “primary or secondary antibody deficiencies”; source: title and abstract.", "evidenceQuotes": [ "The demographics, causes of immunodeficiency, diagnostic delay, clinical and laboratory features, and infection frequency were analysed retrospectively.", "primary or secondary antibody deficiencies", "immunoglobulin (Ig)-replacement treatment", "infection outcomes of immunoglobulin replacement", "primary or secondary antibody deficiencies" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20575086", "title": "Resolution of extensive severe bronchiectasis in an infant.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We describe the case of a young infant”; source: title and abstract. Population: Yes; evidence: “extensive, severe bronchiectasis of unknown etiology”; source: title and abstract. Intervention or exposure: No; evidence: “prolonged treatment with antibiotics and a tapering course of oral steroids”; source: title and abstract. Comparator: No; evidence: “resolved following prolonged treatment”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “unknown etiology”; source: title and abstract.", "evidenceQuotes": [ "We describe the case of a young infant", "extensive, severe bronchiectasis of unknown etiology", "prolonged treatment with antibiotics and a tapering course of oral steroids", "resolved following prolonged treatment", "unknown etiology" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10992538", "title": "Non-specific interstitial pneumonia: findings on sequential CT scans of nine patients.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The purpose of this study was to describe findings on sequential high resolution computed tomographic (CT) scans of nine patients with non-specific interstitial pneumonia.”; source: title and abstract. Population: No; evidence: “nine patients with non-specific interstitial pneumonia”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The purpose of this study was to describe findings on sequential high resolution computed tomographic (CT) scans of nine patients with non-specific interstitial pneumonia.", "nine patients with non-specific interstitial pneumonia" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19138237", "title": "Withdrawal of inhaled steroids in children with non-cystic fibrosis bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Twenty-seven children with steady-state non-CF bronchiectasis were evaluated primarily with metacholine challenge tests and apoptotic neutrophil ratios in induced sputum and secondarily with symptom scores, pulmonary function tests and tumour necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) levels and neutrophil ratios in induced sputum before and after 12-week withdrawal of inhaled steroids.”; source: title and abstract. Population: Yes; evidence: “children with non-cystic fibrosis (non-CF) bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “withdrawal of inhaled steroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non-cystic fibrosis (non-CF) bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "Twenty-seven children with steady-state non-CF bronchiectasis were evaluated primarily with metacholine challenge tests and apoptotic neutrophil ratios in induced sputum and secondarily with symptom scores, pulmonary function tests and tumour necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) levels and neutrophil ratios in induced sputum before and after 12-week withdrawal of inhaled steroids.", "children with non-cystic fibrosis (non-CF) bronchiectasis", "withdrawal of inhaled steroids", "non-cystic fibrosis (non-CF) bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20624789", "title": "Acute exacerbation of chronic obstructive pulmonary disease in primary care setting in Spain: the EPOCAP study.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “An observational, multicenter and cross-sectional study was performed”; source: title and abstract. Population: No; evidence: “patients diagnosed with acute exacerbation of COPD”; source: title and abstract. Intervention or exposure: No; evidence: “inhaled corticosteroids (ICs) (71.3%, n = 776)”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Patients diagnosed with asthma, cystic fibrosis, significant bronchiectasis or pneumonia were not included in the study.”; source: title and abstract.", "evidenceQuotes": [ "An observational, multicenter and cross-sectional study was performed", "patients diagnosed with acute exacerbation of COPD", "inhaled corticosteroids (ICs) (71.3%, n = 776)", "Patients diagnosed with asthma, cystic fibrosis, significant bronchiectasis or pneumonia were not included in the study." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11535970", "title": "Oral neltenexine in patients with obstructive airways diseases: an open, randomised, controlled comparison versus sobrerol.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “open, randomised, controlled comparison”; source: title and abstract. Population: No; evidence: “patients with obstructive airways disease”; source: title and abstract. Intervention or exposure: No; evidence: “neltenexine (oral granules in sachets) as compared with sobrerol (oral granules in sachets)”; source: title and abstract. Comparator: No; evidence: “as compared with sobrerol”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “cystic fibrosis, active tuberculosis or an assessed diagnosis of bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "open, randomised, controlled comparison", "patients with obstructive airways disease", "neltenexine (oral granules in sachets) as compared with sobrerol (oral granules in sachets)", "as compared with sobrerol", "cystic fibrosis, active tuberculosis or an assessed diagnosis of bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "2679608", "title": "Rationale of airway clearance.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The airways are cleared by mucociliary action and coughing.”; source: title and abstract. Population: No; evidence: “patients with chronic obstructive pulmonary disease (COPD)”; source: title and abstract. Intervention or exposure: No; evidence: “Clearance may be improved by drugs such as beta 2-agonists, theophylline, corticosteroids and mucolytics in various disease states.”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The airways are cleared by mucociliary action and coughing.", "patients with chronic obstructive pulmonary disease (COPD)", "Clearance may be improved by drugs such as beta 2-agonists, theophylline, corticosteroids and mucolytics in various disease states." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17129491", "title": "[Cryptogenic organizing pneumonia: CT features and the effect of glucocorticoids].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The diagnosis of COP was made based on clinical and radiological features and confirmed by lung biopsy and pathological examination in 21 cases from 2001 to 2005.”; source: title and abstract. Population: No; evidence: “cryptogenic organizing pneumonia (COP)”; source: title and abstract. Intervention or exposure: No; evidence: “Glucocorticoid treatment resulted in significant improvement in most cases.”; source: title and abstract. Comparator: No; evidence: “CT follow-up was carried out 5 - 75 days following therapy.”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The diagnosis of COP was made based on clinical and radiological features and confirmed by lung biopsy and pathological examination in 21 cases from 2001 to 2005.", "cryptogenic organizing pneumonia (COP)", "Glucocorticoid treatment resulted in significant improvement in most cases.", "CT follow-up was carried out 5 - 75 days following therapy." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11560305", "title": "Diagnosis and treatment of allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Itraconazole has been reported anecdotally to be effective, and evidence for its effectiveness in randomized trials is still accruing.”; source: title and abstract. Population: No; evidence: “Allergic bronchopulmonary aspergillosis (ABPA) is an underdiagnosed pulmonary disorder in asthmatic patients and patients with cystic fibrosis.”; source: title and abstract. Intervention or exposure: No; evidence: “Long-term treatment with corticosteroids is often required for effective management.”; source: title and abstract. Comparator: No; evidence: “Itraconazole has been reported anecdotally to be effective, and evidence for its effectiveness in randomized trials is still accruing.”; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “patients with cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "Itraconazole has been reported anecdotally to be effective, and evidence for its effectiveness in randomized trials is still accruing.", "Allergic bronchopulmonary aspergillosis (ABPA) is an underdiagnosed pulmonary disorder in asthmatic patients and patients with cystic fibrosis.", "Long-term treatment with corticosteroids is often required for effective management.", "Itraconazole has been reported anecdotally to be effective, and evidence for its effectiveness in randomized trials is still accruing.", "patients with cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25584096", "title": "Computed tomography features of pulmonary nocardiosis in immunocompromised and immunocompetent patients.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “pulmonary nocardiosis”; source: title and abstract. Intervention or exposure: No; evidence: “steroid therapy for nephrotic syndrome (n=1)”; source: title and abstract. Comparator: No; evidence: “compared immunocompetent and immunocompromised patients”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "pulmonary nocardiosis", "steroid therapy for nephrotic syndrome (n=1)", "compared immunocompetent and immunocompromised patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9713458", "title": "Bronchiectasis following colectomy for Crohn's disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This may be the first report of bronchiectasis developing after colectomy for Crohn's disease.”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: No; evidence: “an impressive response to oral steroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This may be the first report of bronchiectasis developing after colectomy for Crohn's disease.", "an impressive response to oral steroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19361821", "title": "[Bronchiectasis treatment in adults].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “In practical terms, the treatment of bronchiectasis in adults is based on eight basic pillars...”; source: title and abstract. Population: Yes; evidence: “Bronchiectasis is characterized by the dilation and progressive destruction of the bronchial wall.”; source: title and abstract. Intervention or exposure: Yes; evidence: “treatment of bronchial inflammation (inhaled steroids and macrolides)”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "In practical terms, the treatment of bronchiectasis in adults is based on eight basic pillars...", "Bronchiectasis is characterized by the dilation and progressive destruction of the bronchial wall.", "treatment of bronchial inflammation (inhaled steroids and macrolides)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18059153", "title": "[Case of allergic bronchopulmonary aspergillosis successfully treated with itraconazole].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “central bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “we treated her with the concomitant administration of oral itraconazole and inhaled corticosteroid”; source: title and abstract. Comparator: No; evidence: “we treated her with the concomitant administration of oral itraconazole and inhaled corticosteroid”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "central bronchiectasis", "we treated her with the concomitant administration of oral itraconazole and inhaled corticosteroid", "we treated her with the concomitant administration of oral itraconazole and inhaled corticosteroid" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17234397", "title": "Airway nitric oxide output is reduced in bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: Yes; evidence: “nine patients with stable bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “after inhaled glucocorticoid therapy”; source: title and abstract. Comparator: No; evidence: “before and after inhaled glucocorticoid therapy”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "nine patients with stable bronchiectasis", "after inhaled glucocorticoid therapy", "before and after inhaled glucocorticoid therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "4106992", "title": "Relief of bronchospams by nasal inhalation therapy.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: Title and abstract insufficient to determine study design.; source: title and abstract. Population: Maybe; evidence: No information on population.; source: title and abstract. Intervention or exposure: Maybe; evidence: No information on intervention.; source: title and abstract. Comparator: Maybe; evidence: No information on comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8466099", "title": "Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26585431", "title": "A randomised trial of glucocorticoids in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Yes; evidence: “Treatment-naive ABPA subjects randomly received either high-dose or medium-dose oral prednisolone.”; source: title and abstract. Population: No; evidence: “allergic bronchopulmonary aspergillosis complicating asthma”; source: title and abstract. Intervention or exposure: No; evidence: “oral prednisolone”; source: title and abstract. Comparator: No; evidence: “high-dose or medium-dose oral prednisolone”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Treatment-naive ABPA subjects randomly received either high-dose or medium-dose oral prednisolone.", "allergic bronchopulmonary aspergillosis complicating asthma", "oral prednisolone", "high-dose or medium-dose oral prednisolone" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20658484", "title": "Aerosolized amphotericin for the treatment of allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “This case discusses the successful use of aerosolized amphotericin B for the treatment of ABPA in a 14-year-old patient with CF listed for lung transplant.”; source: title and abstract. Population: No; evidence: “patients with cystic fibrosis (CF)”; source: title and abstract. Intervention or exposure: No; evidence: “aerosolized amphotericin B”; source: title and abstract. Comparator: No; evidence: “The patient required fewer hospitalizations, and both oral corticosteroids and anti-fungal therapy were eventually stopped.”; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “patients with cystic fibrosis (CF)”; source: title and abstract.", "evidenceQuotes": [ "This case discusses the successful use of aerosolized amphotericin B for the treatment of ABPA in a 14-year-old patient with CF listed for lung transplant.", "patients with cystic fibrosis (CF)", "aerosolized amphotericin B", "The patient required fewer hospitalizations, and both oral corticosteroids and anti-fungal therapy were eventually stopped.", "patients with cystic fibrosis (CF)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9730996", "title": "Inhaled fluticasone reduces sputum inflammatory indices in severe bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Yes; evidence: “double-blind, placebo-controlled study”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: Yes; evidence: “inhaled fluticasone (500 microgram twice daily)”; source: title and abstract. Comparator: Yes; evidence: “or placebo”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “in bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "double-blind, placebo-controlled study", "inhaled fluticasone (500 microgram twice daily)", "or placebo", "in bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8975302", "title": "[Bronchial involvement in sarcoidosis. Study with high resolution computerized tomography].", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Sixty-one sarcoidosis patients were submitted to chest radiography and HRCT at onset.”; source: title and abstract. Population: No; evidence: “sarcoidosis patients”; source: title and abstract. Intervention or exposure: No; evidence: “after a cycle of steroid therapy”; source: title and abstract. Comparator: No; evidence: “randomized with 29 patients with diffuse infiltrative lung diseases of different nature”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “sarcoidosis patients”; source: title and abstract.", "evidenceQuotes": [ "Sixty-one sarcoidosis patients were submitted to chest radiography and HRCT at onset.", "sarcoidosis patients", "after a cycle of steroid therapy", "randomized with 29 patients with diffuse infiltrative lung diseases of different nature", "sarcoidosis patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "5269924", "title": "Idiopathic hypogammaglobulinemia, pernicious anemia, arthritis, and diarrhea. Effects of prednisone.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: No abstract available; cannot determine study design.; source: title and abstract. Population: Maybe; evidence: No abstract available; cannot determine population.; source: title and abstract. Intervention or exposure: Maybe; evidence: No abstract available; cannot determine intervention.; source: title and abstract. Comparator: Maybe; evidence: No abstract available; cannot determine comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No abstract available; cannot determine exclusion status.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16088589", "title": "Macrolides as biological response modifiers in cystic fibrosis and bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “There are small case series and three large randomized controlled trials that have established unequivocal evidence of benefit in CF.”; source: title and abstract. Population: Maybe; evidence: “in cystic fibrosis and bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “macrolide antibiotics”; source: title and abstract. Comparator: Maybe; evidence: No specific comparator is mentioned in the abstract.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: “in cystic fibrosis and bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "There are small case series and three large randomized controlled trials that have established unequivocal evidence of benefit in CF.", "in cystic fibrosis and bronchiectasis", "macrolide antibiotics", "in cystic fibrosis and bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9866981", "title": "[Allergic bronchopulmonary aspergillosis effectively treated with itraconazole].", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “A 23-year-old man with bronchial asthma presented with fever, cough, and sputum.”; source: title and abstract. Population: No; evidence: “A 23-year-old man with bronchial asthma presented with fever, cough, and sputum. A chest X-ray examination showed pulmonary infiltrations in the left upper and lower lung fields with central bronchiectasis.”; source: title and abstract. Intervention or exposure: No; evidence: “The patient was treated with itraconazole instead of corticosteroids.”; source: title and abstract. Comparator: No; evidence: “The patient was treated with itraconazole instead of corticosteroids.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “A 23-year-old man with bronchial asthma presented with fever, cough, and sputum.”; source: title and abstract.", "evidenceQuotes": [ "A 23-year-old man with bronchial asthma presented with fever, cough, and sputum.", "A 23-year-old man with bronchial asthma presented with fever, cough, and sputum. A chest X-ray examination showed pulmonary infiltrations in the left upper and lower lung fields with central bronchiectasis.", "The patient was treated with itraconazole instead of corticosteroids.", "The patient was treated with itraconazole instead of corticosteroids.", "A 23-year-old man with bronchial asthma presented with fever, cough, and sputum." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1615177", "title": "Inhaled steroids in patients with bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Yes; evidence: “double-blind, placebo-controlled, cross-over study”; source: title and abstract. Population: Yes; evidence: “20 patients with bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “inhaled beclomethasone diproprionate (1500 micrograms day-1)”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “20 patients with bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "double-blind, placebo-controlled, cross-over study", "20 patients with bronchiectasis", "inhaled beclomethasone diproprionate (1500 micrograms day-1)", "20 patients with bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26354868", "title": "Chronic obstructive pulmonary diseases in children.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Relevant literature from PubMed was selected and reviewed.”; source: title and abstract. Population: Maybe; evidence: “Chronic obstructive pulmonary diseases in children”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Oral and inhaled corticosteroids, bronchodilators, inhaled antibiotics, and treatment of pulmonary exacerbation (PE) are the bases of COPDC management”; source: title and abstract. Comparator: Maybe; evidence: No specific comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Chronic obstructive pulmonary diseases in children”; source: title and abstract.", "evidenceQuotes": [ "Relevant literature from PubMed was selected and reviewed.", "Chronic obstructive pulmonary diseases in children", "Oral and inhaled corticosteroids, bronchodilators, inhaled antibiotics, and treatment of pulmonary exacerbation (PE) are the bases of COPDC management", "Chronic obstructive pulmonary diseases in children" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24570384", "title": "Interstitial lung disease in patients with rheumatoid arthritis: spontaneous and drug induced.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by the destruction of articular joint structures.”; source: title and abstract. Population: No; evidence: “Interstitial lung disease (ILD) is a common occurrence in patients with RA”; source: title and abstract. Intervention or exposure: No; evidence: “Treatment for RA-ILD typically involves the use of high-dose corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Rheumatoid arthritis (RA) is an inflammatory autoimmune disease”; source: title and abstract.", "evidenceQuotes": [ "Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by the destruction of articular joint structures.", "Interstitial lung disease (ILD) is a common occurrence in patients with RA", "Treatment for RA-ILD typically involves the use of high-dose corticosteroids", "Rheumatoid arthritis (RA) is an inflammatory autoimmune disease" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "27246587", "title": "Pulmonary manifestations of Sjögren's syndrome.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease.”; source: title and abstract. Intervention or exposure: No; evidence: “Corticosteroid therapy is the mainstay of ILD treatment”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Sjögren's syndrome”; source: title and abstract.", "evidenceQuotes": [ "The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease.", "Corticosteroid therapy is the mainstay of ILD treatment", "Sjögren's syndrome" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16548837", "title": "Middle lobe syndrome as the pulmonary manifestation of primary Sjögren's syndrome.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We describe a patient in whom lymphocytic bronchiolitis in the atelectatic lobes was proved histologically from two separate transbronchial biopsies.”; source: title and abstract. Population: Maybe; evidence: The patient has bronchiectasis but it is associated with Sjögren's syndrome; unclear if stable and non-CF.; source: title and abstract. Intervention or exposure: No; evidence: “The atelectasis responded well to glucocorticoid treatment”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We describe a patient in whom lymphocytic bronchiolitis in the atelectatic lobes was proved histologically from two separate transbronchial biopsies.", "The atelectasis responded well to glucocorticoid treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "3516103", "title": "Allergic bronchopulmonary aspergillosis. Natural history and classification of early disease by serologic and roentgenographic studies.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Eighty-four patients with allergic bronchopulmonary aspergillosis (ABPA) were evaluated for a total of 294 patient-years with a mean observation period of 3.7 years and classified by the stage of ABPA.”; source: title and abstract. Population: No; evidence: “Eighty-four patients with allergic bronchopulmonary aspergillosis (ABPA) were evaluated”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid-dependent asthma stage”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Eighty-four patients with allergic bronchopulmonary aspergillosis (ABPA) were evaluated for a total of 294 patient-years with a mean observation period of 3.7 years and classified by the stage of ABPA.", "Eighty-four patients with allergic bronchopulmonary aspergillosis (ABPA) were evaluated", "corticosteroid-dependent asthma stage" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25882347", "title": "Microbiology and outcomes of community acquired pneumonia in non cystic-fibrosis bronchiectasis patients.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Prospective observational study of 3495 CAP patients (2000-2011).”; source: title and abstract. Population: Yes; evidence: “non cystic-fibrosis bronchiectasis patients”; source: title and abstract. Intervention or exposure: No; evidence: “inhaled steroids (53% vs. 16%)”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non cystic-fibrosis bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "Prospective observational study of 3495 CAP patients (2000-2011).", "non cystic-fibrosis bronchiectasis patients", "inhaled steroids (53% vs. 16%)", "non cystic-fibrosis bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12832674", "title": "Asymptomatic carriage of Pneumocystis jiroveci in subjects undergoing bronchoscopy: a prospective study.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A prospective observational cohort study was performed”; source: title and abstract. Population: Maybe; evidence: “patients who required bronchoscopy and bronchoalveolar lavage (BAL) as part of their routine clinical assessment”; source: title and abstract. Intervention or exposure: No; evidence: “glucocorticoid use was significantly associated with detectable P jiroveci DNA”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “HIV negative patients”; source: title and abstract.", "evidenceQuotes": [ "A prospective observational cohort study was performed", "patients who required bronchoscopy and bronchoalveolar lavage (BAL) as part of their routine clinical assessment", "glucocorticoid use was significantly associated with detectable P jiroveci DNA", "HIV negative patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9713457", "title": "Bronchiectasis in association with coeliac disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 48 year old woman presented with a history of fatigue, regular sputum production, and wheeze.”; source: title and abstract. Population: Maybe; evidence: “High resolution computed tomographic scanning of the thorax demonstrated widespread bronchiectasis.”; source: title and abstract. Intervention or exposure: Yes; evidence: “following treatment with inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 48 year old woman presented with a history of fatigue, regular sputum production, and wheeze.", "High resolution computed tomographic scanning of the thorax demonstrated widespread bronchiectasis.", "following treatment with inhaled corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "2548426", "title": "Bronchiolitis in adults. A reversible cause of airway obstruction associated with airway neutrophils and neutrophil products.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “16 adult patients were identified who had accelerated onset of a severe respiratory disorder”; source: title and abstract. Population: No; evidence: “clinically distinct from the more commonly encountered chronic obstructive disorders (e.g., chronic bronchitis, emphysema, asthma, bronchiectasis, cystic fibrosis, and alpha 1-antitrypsin deficiency)”; source: title and abstract. Intervention or exposure: No; evidence: “treatment with oral prednisone”; source: title and abstract. Comparator: No; evidence: “Pulmonary function testing and BAL were also repeated after 3 months of treatment with oral prednisone”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "16 adult patients were identified who had accelerated onset of a severe respiratory disorder", "clinically distinct from the more commonly encountered chronic obstructive disorders (e.g., chronic bronchitis, emphysema, asthma, bronchiectasis, cystic fibrosis, and alpha 1-antitrypsin deficiency)", "treatment with oral prednisone", "Pulmonary function testing and BAL were also repeated after 3 months of treatment with oral prednisone" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23761976", "title": "Invasive Aspergillus infections in hospitalized patients with chronic lung disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “single-center, retrospective study”; source: title and abstract. Population: Maybe; evidence: “Patients with chronic lung disease were defined by one of the following descriptive terms: emphysema, asthma, idiopathic lung disease, bronchitis, bronchiectasis, sarcoid, or pulmonary leukostasis.”; source: title and abstract. Intervention or exposure: No; evidence: “The major risk factors for IPA were found to be steroid use”; source: title and abstract. Comparator: No; evidence: “The outcomes of 57 patients with chronic lung disease and 56 immunocompromised patients were compared.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Patients with chronic lung disease were defined by one of the following descriptive terms: emphysema, asthma, idiopathic lung disease, bronchitis, bronchiectasis, sarcoid, or pulmonary leukostasis.”; source: title and abstract.", "evidenceQuotes": [ "single-center, retrospective study", "Patients with chronic lung disease were defined by one of the following descriptive terms: emphysema, asthma, idiopathic lung disease, bronchitis, bronchiectasis, sarcoid, or pulmonary leukostasis.", "The major risk factors for IPA were found to be steroid use", "The outcomes of 57 patients with chronic lung disease and 56 immunocompromised patients were compared.", "Patients with chronic lung disease were defined by one of the following descriptive terms: emphysema, asthma, idiopathic lung disease, bronchitis, bronchiectasis, sarcoid, or pulmonary leukostasis." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22449688", "title": "Massive tension pneumomediastinum.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: No abstract; cannot determine study design.; source: title and abstract. Population: Maybe; evidence: No abstract; cannot determine population.; source: title and abstract. Intervention or exposure: Maybe; evidence: No abstract; cannot determine intervention.; source: title and abstract. Comparator: Maybe; evidence: No abstract; cannot determine comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No abstract; cannot determine exclusion.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "2709164", "title": "Lung injury in dimethyl sulfate poisoning.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Two manual laborers were exposed to dimethyl sulfate during work”; source: title and abstract. Population: No; evidence: “this patient developed persistent productive cough with no evidence of bronchiectasis or bronchial hyperreactivity.”; source: title and abstract. Intervention or exposure: No; evidence: “improved with high-dose methylprednisolone”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “no evidence of bronchiectasis or bronchial hyperreactivity”; source: title and abstract.", "evidenceQuotes": [ "Two manual laborers were exposed to dimethyl sulfate during work", "this patient developed persistent productive cough with no evidence of bronchiectasis or bronchial hyperreactivity.", "improved with high-dose methylprednisolone", "no evidence of bronchiectasis or bronchial hyperreactivity" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16497762", "title": "Cushing's syndrome without excess cortisol.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: No abstract; cannot determine study design.; source: title and abstract. Population: Maybe; evidence: No abstract; cannot determine population.; source: title and abstract. Intervention or exposure: Maybe; evidence: No abstract; cannot determine intervention.; source: title and abstract. Comparator: Maybe; evidence: No abstract; cannot determine comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No abstract; cannot determine exclusion.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15651274", "title": "[A case of subacute idiopathic interstitial pneumonia resistant to steroids, successfully treated with cyclophosphamide].", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “A 47-year-old woman was admitted to our hospital because of dry cough, fever, and subacute, progressive dyspnea.”; source: title and abstract. Population: No; evidence: “subacute idiopathic interstitial pneumonia”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid was administered repetitively”; source: title and abstract. Comparator: No; evidence: “we decided to administer cyclophosphamide (CPA)”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “No signs suggesting the association of collagen vascular diseases were detected.”; source: title and abstract.", "evidenceQuotes": [ "A 47-year-old woman was admitted to our hospital because of dry cough, fever, and subacute, progressive dyspnea.", "subacute idiopathic interstitial pneumonia", "corticosteroid was administered repetitively", "we decided to administer cyclophosphamide (CPA)", "No signs suggesting the association of collagen vascular diseases were detected." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16612769", "title": "Allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Allergic bronchopulmonary aspergillosis is an uncommon but serious respiratory condition characterized by chronic airway inflammation and airway damage”; source: title and abstract. Population: No; evidence: “Allergic bronchopulmonary aspergillosis”; source: title and abstract. Intervention or exposure: No; evidence: “Treatment involves corticosteroids and antifungal therapy”; source: title and abstract. Comparator: No; evidence: “Treatment involves corticosteroids and antifungal therapy”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Allergic bronchopulmonary aspergillosis”; source: title and abstract.", "evidenceQuotes": [ "Allergic bronchopulmonary aspergillosis is an uncommon but serious respiratory condition characterized by chronic airway inflammation and airway damage", "Allergic bronchopulmonary aspergillosis", "Treatment involves corticosteroids and antifungal therapy", "Treatment involves corticosteroids and antifungal therapy", "Allergic bronchopulmonary aspergillosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9230244", "title": "Pulmonary infection with Nocardia species: a report of 10 cases and review.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “The study group comprised 10 consecutive patients with pulmonary nocardiosis”; source: title and abstract. Population: No; evidence: “Pulmonary nocardiosis (PN) is an infrequent and severe infection due to Nocardia spp.”; source: title and abstract. Intervention or exposure: No; evidence: “Four patients were receiving corticosteroid treatment.”; source: title and abstract. Comparator: No; evidence: “Antimicrobial susceptibility testing showed: 100% sensitivity for amikacin; 83% for imipenem; 71% for cefotaxime; and 71% for trimethoprim-sulphamethoxazole.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Chronic obstructive pulmonary disease (COPD), neoplastic disease and human immunodeficiency virus (HIV) infection were the most frequent predisposing factors.”; source: title and abstract.", "evidenceQuotes": [ "The study group comprised 10 consecutive patients with pulmonary nocardiosis", "Pulmonary nocardiosis (PN) is an infrequent and severe infection due to Nocardia spp.", "Four patients were receiving corticosteroid treatment.", "Antimicrobial susceptibility testing showed: 100% sensitivity for amikacin; 83% for imipenem; 71% for cefotaxime; and 71% for trimethoprim-sulphamethoxazole.", "Chronic obstructive pulmonary disease (COPD), neoplastic disease and human immunodeficiency virus (HIV) infection were the most frequent predisposing factors." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24992394", "title": "A Delphi study of pharmacotherapy for noncystic fibrosis bronchiectasis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “we performed a Delphi study of clinical experts”; source: title and abstract. Population: Yes; evidence: “noncystic fibrosis bronchiectasis (NCFB)”; source: title and abstract. Intervention or exposure: No; evidence: “inhaled corticosteroids should not be routinely used for NCFB”; source: title and abstract. Comparator: No; evidence: “recommended treatment end points for NCFB include sputum volume, sputum color and exacerbation frequency”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “noncystic fibrosis bronchiectasis (NCFB)”; source: title and abstract.", "evidenceQuotes": [ "we performed a Delphi study of clinical experts", "noncystic fibrosis bronchiectasis (NCFB)", "inhaled corticosteroids should not be routinely used for NCFB", "recommended treatment end points for NCFB include sputum volume, sputum color and exacerbation frequency", "noncystic fibrosis bronchiectasis (NCFB)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23918112", "title": "Uncommon pulmonary presentation of IgG4-related disease in a 15-year-old boy.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Here, we report an adolescent presenting with recurrent dry cough and hemoptysis”; source: title and abstract. Population: Yes; evidence: “diffuse bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “Sustained high levels of IgG4 (1,090 mg/dL) were found”; source: title and abstract. Comparator: No; evidence: “Sustained high levels of IgG4 (1,090 mg/dL) were found”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “diffuse bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "Here, we report an adolescent presenting with recurrent dry cough and hemoptysis", "diffuse bronchiectasis", "Sustained high levels of IgG4 (1,090 mg/dL) were found", "Sustained high levels of IgG4 (1,090 mg/dL) were found", "diffuse bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20463254", "title": "Allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Allergic bronchopulmonary aspergillosis (ABPA) is a complex clinical entity...”; source: title and abstract. Population: No; evidence: “most often occurring in a patient with asthma or cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “Early recognition allows treatment with corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “most often occurring in a patient with asthma or cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "Allergic bronchopulmonary aspergillosis (ABPA) is a complex clinical entity...", "most often occurring in a patient with asthma or cystic fibrosis", "Early recognition allows treatment with corticosteroids", "most often occurring in a patient with asthma or cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11822102", "title": "[Is the lung a target organ in inflammatory bowel disease?].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Inflammatory bowel disease is a systemic illness that may involve the lung.”; source: title and abstract. Population: No; evidence: “Some patients show a bronchial inflammation and suppuration with or without bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “responding dramatically to inhaled steroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Inflammatory bowel disease is a systemic illness that may involve the lung.", "Some patients show a bronchial inflammation and suppuration with or without bronchiectasis", "responding dramatically to inhaled steroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22640852", "title": "The use of antiinflammatory therapy and macrolides in bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This article addresses the use of anti-inflammatory/immunomodulatory therapies”; source: title and abstract. Population: Yes; evidence: “patients with bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: “discusses the use of corticosteroids, macrolides, and other potential anti-inflammatory agents”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This article addresses the use of anti-inflammatory/immunomodulatory therapies", "patients with bronchiectasis", "discusses the use of corticosteroids, macrolides, and other potential anti-inflammatory agents" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16218418", "title": "[A case of yellow nail syndrome associated with eosinophilic bronchial disease successfully treated with clarithromycin and budesonide].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 78-year-old man was referred to our hospital...”; source: title and abstract. Population: No; evidence: “yellow nail syndrome was diagnosed”; source: title and abstract. Intervention or exposure: No; evidence: “additional therapy with 800 microg/day budesonide”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 78-year-old man was referred to our hospital...", "yellow nail syndrome was diagnosed", "additional therapy with 800 microg/day budesonide" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7767536", "title": "Elevated levels of exhaled nitric oxide in bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We have measured exhaled NO in patients with documented bronchiectasis”; source: title and abstract. Population: Yes; evidence: “patients with documented bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “patients treated with inhaled steroids”; source: title and abstract. Comparator: No; evidence: “compared with values for 79 normal subjects”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We have measured exhaled NO in patients with documented bronchiectasis", "patients with documented bronchiectasis", "patients treated with inhaled steroids", "compared with values for 79 normal subjects" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20576419", "title": "Beneficial effect of inhaled mannitol and cough in asthmatics with mucociliary dysfunction.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This study investigated the effect of mannitol and cough in asthmatics with mucociliary dysfunction.”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: No; evidence: “Inhaled mannitol improves mucus clearance”; source: title and abstract. Comparator: Maybe; evidence: The abstract does not clearly describe a placebo or no-medication comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “without the diagnosis of bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "This study investigated the effect of mannitol and cough in asthmatics with mucociliary dysfunction.", "Inhaled mannitol improves mucus clearance", "without the diagnosis of bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22046624", "title": "Effects of combination of fluticasone propionate and salmeterol xinafoate on lung function improvement in patients with bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “participated in this prospective quasi-experimental trial”; source: title and abstract. Population: Yes; evidence: “Twelve patients with bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: No; evidence: “comparing and interpreting pulmonary function tests before and after FLU/SAL inhalation”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Twelve patients with bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "participated in this prospective quasi-experimental trial", "Twelve patients with bronchiectasis", "comparing and interpreting pulmonary function tests before and after FLU/SAL inhalation", "Twelve patients with bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11796435", "title": "Exhaled H(2)O(2) in steady-state bronchiectasis: relationship with cellular composition in induced sputum, spirometry, and extent and severity of disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Design: Cross-sectional study.”; source: title and abstract. Population: Yes; evidence: “Thirty patients with steady-state bronchiectasis.”; source: title and abstract. Intervention or exposure: No; evidence: “to account for possible confounding effects of inhaled corticosteroids (ICS) usage”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Thirty patients with steady-state bronchiectasis.”; source: title and abstract.", "evidenceQuotes": [ "Design: Cross-sectional study.", "Thirty patients with steady-state bronchiectasis.", "to account for possible confounding effects of inhaled corticosteroids (ICS) usage", "Thirty patients with steady-state bronchiectasis." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15357269", "title": "[A case of Crohn's disease with broncho-bronchiolitis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 41-year old man was hospitalized for abdominal pain and melena.”; source: title and abstract. Population: No; evidence: “A 41-year old man was hospitalized for abdominal pain and melena.”; source: title and abstract. Intervention or exposure: No; evidence: “steroid pulse therapy was initiated in combination with azathioprine”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “A 41-year old man was hospitalized for abdominal pain and melena.”; source: title and abstract.", "evidenceQuotes": [ "A 41-year old man was hospitalized for abdominal pain and melena.", "A 41-year old man was hospitalized for abdominal pain and melena.", "steroid pulse therapy was initiated in combination with azathioprine", "A 41-year old man was hospitalized for abdominal pain and melena." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8695990", "title": "Long-term pulmonary function in children with Hodgkin's disease.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We studied the long-term pulmonary function of 25 patients who were at least 5 years post-treatment for Hodgkin's disease.”; source: title and abstract. Population: No; evidence: “One patient had symptoms of bronchiectasia.”; source: title and abstract. Intervention or exposure: No; evidence: “All patients received six courses of COPP chemotherapy and, in addition, 8 of the 25 patients received radiotherapy to the mediastinum”; source: title and abstract. Comparator: No; evidence: “We divided patients into two groups while evaluating their pulmonary function tests according to whether they received mantle irradiation or not.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “One patient had symptoms of bronchiectasia.”; source: title and abstract.", "evidenceQuotes": [ "We studied the long-term pulmonary function of 25 patients who were at least 5 years post-treatment for Hodgkin's disease.", "One patient had symptoms of bronchiectasia.", "All patients received six courses of COPP chemotherapy and, in addition, 8 of the 25 patients received radiotherapy to the mediastinum", "We divided patients into two groups while evaluating their pulmonary function tests according to whether they received mantle irradiation or not.", "One patient had symptoms of bronchiectasia." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10325928", "title": "Inhaled corticosteroids in COPD.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: Title mentions inhaled corticosteroids in COPD, but no abstract; cannot determine if RCT.; source: title and abstract. Population: Maybe; evidence: Title mentions COPD, not bronchiectasis; no abstract to confirm.; source: title and abstract. Intervention or exposure: Yes; evidence: “Inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: No abstract; comparator not mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No abstract; cannot determine if cystic fibrosis excluded.; source: title and abstract.", "evidenceQuotes": [ "Inhaled corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25326560", "title": "Tracheobronchitis as an extraintestinal manifestation of ulcerative colitis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present a case of a 21-year-old woman”; source: title and abstract. Population: No; evidence: “Respiratory involvement is a rare extraintestinal manifestation of ulcerative colitis (UC). It commonly presents as bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “It responds well to immunosuppressive therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We present a case of a 21-year-old woman", "Respiratory involvement is a rare extraintestinal manifestation of ulcerative colitis (UC). It commonly presents as bronchiectasis", "It responds well to immunosuppressive therapy" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8190039", "title": "Bronchiectasis. A late feature of severe rheumatoid arthritis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We identified 23 patients with rheumatoid arthritis and bronchiectasis at the Brigham and Women's Hospital followed between 1984 and 1991”; source: title and abstract. Population: Yes; evidence: “23 patients with rheumatoid arthritis and bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “In addition to standard treatment regimens, 17 patients had received corticosteroids.”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We identified 23 patients with rheumatoid arthritis and bronchiectasis at the Brigham and Women's Hospital followed between 1984 and 1991", "23 patients with rheumatoid arthritis and bronchiectasis", "In addition to standard treatment regimens, 17 patients had received corticosteroids." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10612158", "title": "[Bronchiectasis in a patient with ulcerative colitis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report a case of a 65-year-old patient with ulcerative colitis in whom we diagnosed bronchiectasis.”; source: title and abstract. Population: Yes; evidence: “a 65-year-old patient with ulcerative colitis in whom we diagnosed bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “their improvement after inhaled corticosteroid treatment”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned in the abstract.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “without pulmonary history”; source: title and abstract.", "evidenceQuotes": [ "We report a case of a 65-year-old patient with ulcerative colitis in whom we diagnosed bronchiectasis.", "a 65-year-old patient with ulcerative colitis in whom we diagnosed bronchiectasis", "their improvement after inhaled corticosteroid treatment", "without pulmonary history" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7828702", "title": "Severe inflammatory upper airway stenosis in ulcerative colitis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Severe upper airway stenosis was diagnosed in a 23 year old woman”; source: title and abstract. Population: Yes; evidence: “occasionally develops into bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “Systemic corticosteroids led to rapid clinical improvement”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “ulcerative colitis”; source: title and abstract.", "evidenceQuotes": [ "Severe upper airway stenosis was diagnosed in a 23 year old woman", "occasionally develops into bronchiectasis", "Systemic corticosteroids led to rapid clinical improvement", "ulcerative colitis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17882908", "title": "Allergic fungal sinusitis associated with allergic bronchopulmonary aspergillosis: an uncommon sinobronchial allergic mycosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “The identification of allergic fungal sinusitis (AFS) is still controversial and much more recent than that of allergic bronchopulmonary aspergillosis (ABPA). Their association has been reported very rarely in the literature. Methods: The aim of this study was to present a review of 6 cases of AFS associated with ABPA from a series of 12 cases of AFS and to compare AFS associated with ABPA and isolated AFS.”; source: title and abstract. Population: No; evidence: “All cases of AFS presented with chronic rhinosinusitis. The six cases with AFS and ABPA were atopic, asthmatic, with pulmonary infiltrates (five cases), central bronchiectasis (four cases), and both (three cases).”; source: title and abstract. Intervention or exposure: No; evidence: “The treatment with oral corticosteroids and sinus surgery (six cases) associated with antifungal drugs (four cases) led to resolution in three cases, considerable improvement in one case, and therapeutic failure in two cases”; source: title and abstract. Comparator: No; evidence: “The treatment with oral corticosteroids and sinus surgery (six cases) associated with antifungal drugs (four cases) led to resolution in three cases, considerable improvement in one case, and therapeutic failure in two cases”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “The six cases with AFS and ABPA were atopic, asthmatic, with pulmonary infiltrates (five cases), central bronchiectasis (four cases), and both (three cases).”; source: title and abstract.", "evidenceQuotes": [ "The identification of allergic fungal sinusitis (AFS) is still controversial and much more recent than that of allergic bronchopulmonary aspergillosis (ABPA). Their association has been reported very rarely in the literature. Methods: The aim of this study was to present a review of 6 cases of AFS associated with ABPA from a series of 12 cases of AFS and to compare AFS associated with ABPA and isolated AFS.", "All cases of AFS presented with chronic rhinosinusitis. The six cases with AFS and ABPA were atopic, asthmatic, with pulmonary infiltrates (five cases), central bronchiectasis (four cases), and both (three cases).", "The treatment with oral corticosteroids and sinus surgery (six cases) associated with antifungal drugs (four cases) led to resolution in three cases, considerable improvement in one case, and therapeutic failure in two cases", "The treatment with oral corticosteroids and sinus surgery (six cases) associated with antifungal drugs (four cases) led to resolution in three cases, considerable improvement in one case, and therapeutic failure in two cases", "The six cases with AFS and ABPA were atopic, asthmatic, with pulmonary infiltrates (five cases), central bronchiectasis (four cases), and both (three cases)." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "27759640", "title": "Combined inhaled corticosteroid and long-acting β2-adrenergic agonist therapy for noncystic fibrosis bronchiectasis with airflow limitation: An observational study.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “An observational study was performed in 120 non-CF bronchiectasis patients diagnosed by high-resolution computed tomography (HRCT) scanning of the chest.”; source: title and abstract. Population: Yes; evidence: “non-CF bronchiectasis patients diagnosed by high-resolution computed tomography (HRCT) scanning of the chest”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non-CF bronchiectasis patients”; source: title and abstract.", "evidenceQuotes": [ "An observational study was performed in 120 non-CF bronchiectasis patients diagnosed by high-resolution computed tomography (HRCT) scanning of the chest.", "non-CF bronchiectasis patients diagnosed by high-resolution computed tomography (HRCT) scanning of the chest", "non-CF bronchiectasis patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26816298", "title": "Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Yes; evidence: “All randomised controlled trials comparing inhaled NSAIDs versus a control (placebo or usual treatment) in children or adults with bronchiectasis not related to cystic fibrosis.”; source: title and abstract. Population: Yes; evidence: “children or adults with bronchiectasis not related to cystic fibrosis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Yes; evidence: “placebo or usual treatment”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “bronchiectasis not related to cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "All randomised controlled trials comparing inhaled NSAIDs versus a control (placebo or usual treatment) in children or adults with bronchiectasis not related to cystic fibrosis.", "children or adults with bronchiectasis not related to cystic fibrosis", "placebo or usual treatment", "bronchiectasis not related to cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25456559", "title": "Computed tomography image analysis before and after treatment of anti-neutrophil cytoplasmic antibody-associated pulmonary interstitial fibrosis in 8 patients.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The clinical features and computed tomography imaging findings of the 8 patients in our hospital from October 2011 to October 2013, were retrospectively analyzed.”; source: title and abstract. Population: No; evidence: “anti-neutrophil cytoplasmic antibody (ANCA)-associated pulmonary interstitial fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid or immunosuppressive therapy”; source: title and abstract. Comparator: No; evidence: “The ground-glass opacities disappeared after corticosteroid or immunosuppressive therapy; however, for streaks and grid shadows, no significant changes in the images were observed after treatment from 2 weeks to 10 months.”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The clinical features and computed tomography imaging findings of the 8 patients in our hospital from October 2011 to October 2013, were retrospectively analyzed.", "anti-neutrophil cytoplasmic antibody (ANCA)-associated pulmonary interstitial fibrosis", "corticosteroid or immunosuppressive therapy", "The ground-glass opacities disappeared after corticosteroid or immunosuppressive therapy; however, for streaks and grid shadows, no significant changes in the images were observed after treatment from 2 weeks to 10 months." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22781123", "title": "Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This study examined chronic respiratory diseases and ICS use as risk factors in a population-based case-control study”; source: title and abstract. Population: No; evidence: “all adults in Denmark with microbiologically confirmed NTM pulmonary disease”; source: title and abstract. Intervention or exposure: Yes; evidence: “inhaled corticosteroid (ICS) therapy”; source: title and abstract. Comparator: Yes; evidence: “10 matched population controls per case”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This study examined chronic respiratory diseases and ICS use as risk factors in a population-based case-control study", "all adults in Denmark with microbiologically confirmed NTM pulmonary disease", "inhaled corticosteroid (ICS) therapy", "10 matched population controls per case" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21364311", "title": "Centrilobular opacities in the asthmatic lung successfully treated with inhaled ciclesonide and tiotropium: with assessment of alveolar nitric oxide levels.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Case summary: A previously healthy 64-year-old man presented with a four-month history of productive cough and progressive dyspnea”; source: title and abstract. Population: No; evidence: “bronchiectatic changes”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Case summary: A previously healthy 64-year-old man presented with a four-month history of productive cough and progressive dyspnea", "bronchiectatic changes" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19323585", "title": "Pharmacological treatment options for bronchiectasis: focus on antimicrobial and anti-inflammatory agents.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Pharmacological treatment options for bronchiectasis: focus on antimicrobial and anti-inflammatory agents.”; source: title and abstract. Population: Yes; evidence: “Patients with bronchiectasis experience tenacious mucus, recurrent infectious exacerbations, and progressive worsening of symptoms and obstruction over time.”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Other mucoactive and anti-inflammatory agents, such as inhaled corticosteroids, mannitol and hypertonic saline, may also prove useful in this disease”; source: title and abstract. Comparator: Maybe; evidence: No specific comparator is discussed.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Patients with bronchiectasis experience tenacious mucus, recurrent infectious exacerbations, and progressive worsening of symptoms and obstruction over time.”; source: title and abstract.", "evidenceQuotes": [ "Pharmacological treatment options for bronchiectasis: focus on antimicrobial and anti-inflammatory agents.", "Patients with bronchiectasis experience tenacious mucus, recurrent infectious exacerbations, and progressive worsening of symptoms and obstruction over time.", "Other mucoactive and anti-inflammatory agents, such as inhaled corticosteroids, mannitol and hypertonic saline, may also prove useful in this disease", "Patients with bronchiectasis experience tenacious mucus, recurrent infectious exacerbations, and progressive worsening of symptoms and obstruction over time." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21778259", "title": "Clinical efficacy and safety of budesonide-formoterol in non-cystic fibrosis bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Yes; evidence: “This is a 12-month randomized, double-blind, parallel-groups clinical trial”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “patients with non-cystic fibrosis (non-CF) bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "This is a 12-month randomized, double-blind, parallel-groups clinical trial", "patients with non-cystic fibrosis (non-CF) bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9828857", "title": "Increases in CD4+ T lymphocytes, macrophages, neutrophils and interleukin 8 positive cells in the airways of patients with bronchiectasis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Bronchial mucosal biopsy specimens were obtained by fibreoptic bronchoscopy from 12 patients with bronchiectasis (six receiving inhaled steroids) and 11 normal healthy controls.”; source: title and abstract. Population: Yes; evidence: “12 patients with bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “six receiving inhaled steroids”; source: title and abstract. Comparator: No; evidence: “six receiving inhaled steroids) and 11 normal healthy controls”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “12 patients with bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "Bronchial mucosal biopsy specimens were obtained by fibreoptic bronchoscopy from 12 patients with bronchiectasis (six receiving inhaled steroids) and 11 normal healthy controls.", "12 patients with bronchiectasis", "six receiving inhaled steroids", "six receiving inhaled steroids) and 11 normal healthy controls", "12 patients with bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "9157669", "title": "[Disseminated pulmonary process developing in concurrent diseases and their multimodal treatment].", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The title is in brackets and the abstract is null, so the study design cannot be determined.; source: title and abstract. Population: Maybe; evidence: No abstract available; cannot determine if the population has bronchiectasis.; source: title and abstract. Intervention or exposure: Maybe; evidence: No abstract available; cannot determine if inhaled corticosteroids are used.; source: title and abstract. Comparator: Maybe; evidence: No abstract available; cannot determine comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No abstract available; cannot determine if cystic fibrosis is excluded.; source: title and abstract.", "evidenceQuotes": [] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "398098", "title": "[Frequency of fungal infection in chronic bronchitis and bronchiectasis (author's transl)].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Among 1 161 patients with chronic bronchitis and 172 patients with bronchiectasis treated for a longer time with antibiotics or with antibiotics and corticosteroids and examined all for fungi in bronchial secretion”; source: title and abstract. Population: Yes; evidence: “patients with chronic bronchitis and 172 patients with bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “treated for a longer time with antibiotics or with antibiotics and corticosteroids”; source: title and abstract. Comparator: No; evidence: “treated for a longer time with antibiotics or with antibiotics and corticosteroids”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Among 1 161 patients with chronic bronchitis and 172 patients with bronchiectasis treated for a longer time with antibiotics or with antibiotics and corticosteroids and examined all for fungi in bronchial secretion", "patients with chronic bronchitis and 172 patients with bronchiectasis", "treated for a longer time with antibiotics or with antibiotics and corticosteroids", "treated for a longer time with antibiotics or with antibiotics and corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19301932", "title": "The role of inhaled corticosteroids in the management of cystic fibrosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This review provides an overview”; source: title and abstract. Population: No; evidence: “The lung disease of cystic fibrosis (CF) is characterized by a vicious cycle of airway obstruction, chronic bacterial infection, and vigorous inflammation, which ultimately results in bronchiectasis.”; source: title and abstract. Intervention or exposure: Yes; evidence: “Inhaled corticosteroids (ICS) are a widely prescribed anti-inflammatory agent in CF”; source: title and abstract. Comparator: Maybe; evidence: The abstract does not mention a comparator group.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “The lung disease of cystic fibrosis (CF) is characterized”; source: title and abstract.", "evidenceQuotes": [ "This review provides an overview", "The lung disease of cystic fibrosis (CF) is characterized by a vicious cycle of airway obstruction, chronic bacterial infection, and vigorous inflammation, which ultimately results in bronchiectasis.", "Inhaled corticosteroids (ICS) are a widely prescribed anti-inflammatory agent in CF", "The lung disease of cystic fibrosis (CF) is characterized" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11535971", "title": "Neltenexine tablets in smoking and non-smoking patients with COPD. A double-blind, randomised, controlled study versus placebo.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: Yes; evidence: “double-blind, randomised, controlled study vs placebo”; source: title and abstract. Population: No; evidence: “The exclusion criteria were lung cancer, pulmonary tuberculosis, asthma, cystic fibrosis, bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “neltenexine (tablets) versus placebo (tablets)”; source: title and abstract. Comparator: Yes; evidence: “versus placebo”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “The exclusion criteria were lung cancer, pulmonary tuberculosis, asthma, cystic fibrosis, bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "double-blind, randomised, controlled study vs placebo", "The exclusion criteria were lung cancer, pulmonary tuberculosis, asthma, cystic fibrosis, bronchiectasis", "neltenexine (tablets) versus placebo (tablets)", "versus placebo", "The exclusion criteria were lung cancer, pulmonary tuberculosis, asthma, cystic fibrosis, bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12486380", "title": "[Bronchectasia and microscopic polyangeitis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report our observations in two patients”; source: title and abstract. Population: Yes; evidence: “two patients who presented with concomitant bronchectasia”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report our observations in two patients", "two patients who presented with concomitant bronchectasia" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22809423", "title": "Emerging drugs for bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “In this review”; source: title and abstract. Population: Yes; evidence: “Bronchiectasis, the destruction and dilation of airways”; source: title and abstract. Intervention or exposure: Maybe; evidence: “We discuss the quality and extent of evidence supporting current treatment strategies”; source: title and abstract. Comparator: Maybe; evidence: No specific comparator is mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "In this review", "Bronchiectasis, the destruction and dilation of airways", "We discuss the quality and extent of evidence supporting current treatment strategies" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16802778", "title": "Contemporaneous occurrence of allergic bronchopulmonary aspergillosis, allergic Aspergillus sinusitis, and aspergilloma.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The coexistence of allergic bronchopulmonary aspergillosis (ABPA) with aspergilloma is uncommon, whereas concurrent ABPA and allergic Aspergillus sinusitis (AAS) is rare.”; source: title and abstract. Population: No; evidence: “A 26-year-old man who had asthma and rhinitis since childhood presented with hemoptysis.”; source: title and abstract. Intervention or exposure: No; evidence: “Spirometry, radiography, computed tomography, skin allergy testing with Aspergillus antigens, serum precipitins against Aspergillus, total and specific IgE, functional endoscopic sinus surgery, and fungal culture were performed.”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The coexistence of allergic bronchopulmonary aspergillosis (ABPA) with aspergilloma is uncommon, whereas concurrent ABPA and allergic Aspergillus sinusitis (AAS) is rare.", "A 26-year-old man who had asthma and rhinitis since childhood presented with hemoptysis.", "Spirometry, radiography, computed tomography, skin allergy testing with Aspergillus antigens, serum precipitins against Aspergillus, total and specific IgE, functional endoscopic sinus surgery, and fungal culture were performed." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23166431", "title": "Membranous nephropathy in a 13-year-old boy with common variable immunodeficiency.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report a 13-yr-old boy with membranous nephropathy and common variable immunodeficiency.”; source: title and abstract. Population: No; evidence: “He presented with the nephrotic syndrome, pneumonia with bronchiectasis, and profound hypogammaglobulinemia.”; source: title and abstract. Intervention or exposure: No; evidence: “Cyclosporine and intravenous immunoglobulin were added”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report a 13-yr-old boy with membranous nephropathy and common variable immunodeficiency.", "He presented with the nephrotic syndrome, pneumonia with bronchiectasis, and profound hypogammaglobulinemia.", "Cyclosporine and intravenous immunoglobulin were added" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16362444", "title": "Juvenile rheumatoid arthritis and bronchiolitis obliterans organized pneumonia.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We described a patient with JRA who developed a BOOP.”; source: title and abstract. Population: No; evidence: “Diverse pleuropulmonary manifestations, including pleural effusion, rheumatoid nodulosis, fibrosis, obliterans brochiolitis, bronchiectasias, vasculitis, drug-induced lung disease, and obliterans bronchiolitis with organized pneumonia, have been described in patients with rheumatoid arthritis (RA).”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We described a patient with JRA who developed a BOOP.", "Diverse pleuropulmonary manifestations, including pleural effusion, rheumatoid nodulosis, fibrosis, obliterans brochiolitis, bronchiectasias, vasculitis, drug-induced lung disease, and obliterans bronchiolitis with organized pneumonia, have been described in patients with rheumatoid arthritis (RA)." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22333650", "title": "[A case of irinotecan or panitumumab-induced interstitial pneumonia successfully treated by steroid pulse therapy].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report a case of a 58-year-old man suffering from advanced colon cancer with liver metastases.”; source: title and abstract. Population: No; evidence: “Computed tomography showed ground-glass opacities and traction bronchiectasis in both lung fields.”; source: title and abstract. Intervention or exposure: No; evidence: “Corticosteroid therapy consisting of methyl- prednisolone(1 g/day)administered for three days was significantly effective”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report a case of a 58-year-old man suffering from advanced colon cancer with liver metastases.", "Computed tomography showed ground-glass opacities and traction bronchiectasis in both lung fields.", "Corticosteroid therapy consisting of methyl- prednisolone(1 g/day)administered for three days was significantly effective" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24862414", "title": "Uncontrolled asthma and recurring pulmonary opacities: just asthma?", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This case report describes a delay in diagnosing ABPA which was imitating pneumonia.”; source: title and abstract. Population: No; evidence: “In patients with uncontrolled atopic asthma with recurring episodes of symptoms mimicking pneumonia, the suspicion of allergic bronchopulmonary aspergillosis (ABPA) should remain high.”; source: title and abstract. Intervention or exposure: No; evidence: “The clinician should pay increased attention to ABPA and test for this in patients with uncontrolled asthma with an ongoing requirement for oral corticosteroids and/or antibiotics”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This case report describes a delay in diagnosing ABPA which was imitating pneumonia.", "In patients with uncontrolled atopic asthma with recurring episodes of symptoms mimicking pneumonia, the suspicion of allergic bronchopulmonary aspergillosis (ABPA) should remain high.", "The clinician should pay increased attention to ABPA and test for this in patients with uncontrolled asthma with an ongoing requirement for oral corticosteroids and/or antibiotics" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26742190", "title": "Pleural Effusion In A Patient With Primary Sjögren's Syndrome Successfully Treated With Corticosteroids.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “primary Sjögren's syndrome”; source: title and abstract. Intervention or exposure: No; evidence: “daily administration of 20 mg of oral prednisone”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "primary Sjögren's syndrome", "daily administration of 20 mg of oral prednisone" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21798654", "title": "[Treatment of non-cystic fibrosis bronchiectasis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The treatment of the colonization and chronic bronchial infection in these patients should be based on prolonged antibiotic therapy”; source: title and abstract. Population: Yes; evidence: “non-cystic fibrosis bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “prolonged antibiotic therapy”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non-cystic fibrosis bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "The treatment of the colonization and chronic bronchial infection in these patients should be based on prolonged antibiotic therapy", "non-cystic fibrosis bronchiectasis", "prolonged antibiotic therapy", "non-cystic fibrosis bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16088725", "title": "Use of guidelines and risk stratification in acute exacerbations of chronic obstructive pulmonary disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Guidelines have been developed”; source: title and abstract. Population: Maybe; evidence: “chronic suppurative airway disease (mainly bronchiectasis)”; source: title and abstract. Intervention or exposure: No; evidence: “antimicrobial treatment decision”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Guidelines have been developed", "chronic suppurative airway disease (mainly bronchiectasis)", "antimicrobial treatment decision" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11529438", "title": "Allergic bronchopulmonary aspergillosis with cavitary lesion simulating a lung abscess.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 48-year-old female patient was diagnosed”; source: title and abstract. Population: No; evidence: “allergic bronchopulmonary aspergillosis (ABPA)”; source: title and abstract. Intervention or exposure: No; evidence: “treatment with corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 48-year-old female patient was diagnosed", "allergic bronchopulmonary aspergillosis (ABPA)", "treatment with corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11244735", "title": "[Three cases of primary acute pulmonary cavitation in sarcoidosis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “we describe three cases”; source: title and abstract. Population: No; evidence: “sarcoidosis”; source: title and abstract. Intervention or exposure: No; evidence: “Corticosteroid therapy was given”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "we describe three cases", "sarcoidosis", "Corticosteroid therapy was given" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24670577", "title": "Effect of inhalers on the development of haemoptysis in patients with non-cystic fibrosis bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “In a case-crossover study of 192 non-CF bronchiectasis patients”; source: title and abstract. Population: Yes; evidence: “patients with non-cystic fibrosis (CF) bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: No; evidence: “The case and control periods were defined respectively as 030 and 180210 days before haemoptysis.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non-cystic fibrosis (CF) bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "In a case-crossover study of 192 non-CF bronchiectasis patients", "patients with non-cystic fibrosis (CF) bronchiectasis", "The case and control periods were defined respectively as 030 and 180210 days before haemoptysis.", "non-cystic fibrosis (CF) bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12673411", "title": "Clinical analysis of pulmonary Mycobacterium avium complex disease in association with corticosteroid treatment.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We studied the clinical characteristics of nine patients”; source: title and abstract. Population: Maybe; evidence: “pulmonary Mycobacterium avium complex disease occurring in association with corticosteroid drugs”; source: title and abstract. Intervention or exposure: Yes; evidence: “corticosteroid treatment”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We studied the clinical characteristics of nine patients", "pulmonary Mycobacterium avium complex disease occurring in association with corticosteroid drugs", "corticosteroid treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17622756", "title": "Bone mineral density in children with non-cystic fibrosis bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: Yes; evidence: “children with non-cystic fibrosis bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “All except 2 children (94%) were receiving inhaled steroids.”; source: title and abstract. Comparator: No; evidence: “23 healthy controls matched for age, sex and pubertal stage”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non-cystic fibrosis bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "children with non-cystic fibrosis bronchiectasis", "All except 2 children (94%) were receiving inhaled steroids.", "23 healthy controls matched for age, sex and pubertal stage", "non-cystic fibrosis bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26549342", "title": "Eosinophilic Granulomatosis with Polyangiitis preceding allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “Eosinophilic Granulomatosis with Polyangiitis (EGPA) and asthma”; source: title and abstract. Intervention or exposure: Yes; evidence: “Prednisolone 0.5 mg/kg/day and Itraconazole”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Eosinophilic Granulomatosis with Polyangiitis (EGPA) and asthma", "Prednisolone 0.5 mg/kg/day and Itraconazole" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25836610", "title": "Thin-section computed tomography detects long-term pulmonary sequelae 3 years after novel influenza A virus-associated pneumonia.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “patients hospitalized with H1N1 virus-associated pneumonia”; source: title and abstract. Intervention or exposure: Yes; evidence: “cumulative prednisolone-equivalent dose”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "patients hospitalized with H1N1 virus-associated pneumonia", "cumulative prednisolone-equivalent dose" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "5577681", "title": "Eosinophilic infiltrations of the lungs in asthmatics.", "abstractAvailable": false, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Eosinophilic infiltrations of the lungs in asthmatics.”; source: title and abstract. Population: No; evidence: “Eosinophilic infiltrations of the lungs in asthmatics.”; source: title and abstract. Intervention or exposure: No; evidence: “Eosinophilic infiltrations of the lungs in asthmatics.”; source: title and abstract. Comparator: No; evidence: “Eosinophilic infiltrations of the lungs in asthmatics.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Eosinophilic infiltrations of the lungs in asthmatics.”; source: title and abstract.", "evidenceQuotes": [ "Eosinophilic infiltrations of the lungs in asthmatics.", "Eosinophilic infiltrations of the lungs in asthmatics.", "Eosinophilic infiltrations of the lungs in asthmatics.", "Eosinophilic infiltrations of the lungs in asthmatics.", "Eosinophilic infiltrations of the lungs in asthmatics." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22059188", "title": "Yellow nail syndrome: dystrophic nails, peripheral lymphedema and chronic cough.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “A case involving a 41-year-old man with yellow nail syndrome (YNS) is reported.”; source: title and abstract. Population: Yes; evidence: “bronchiectasis with recurrent lower respiratory tract infections”; source: title and abstract. Intervention or exposure: No; evidence: “An interdisciplinary approach is required to recognize and collate the components of the syndrome accurately.”; source: title and abstract. Comparator: No; evidence: “An interdisciplinary approach is required to recognize and collate the components of the syndrome accurately.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “A case involving a 41-year-old man with yellow nail syndrome (YNS) is reported.”; source: title and abstract.", "evidenceQuotes": [ "A case involving a 41-year-old man with yellow nail syndrome (YNS) is reported.", "bronchiectasis with recurrent lower respiratory tract infections", "An interdisciplinary approach is required to recognize and collate the components of the syndrome accurately.", "An interdisciplinary approach is required to recognize and collate the components of the syndrome accurately.", "A case involving a 41-year-old man with yellow nail syndrome (YNS) is reported." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22455941", "title": "[A clinical analysis of 7 cases of allergic bronchopulmonary aspergillosis].", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “The clinical presentations, serologic results, chest radiology, pathological results and treatment of 7 patients with ABPA in Chinese PLA General Hospital were retrospectively analyzed.”; source: title and abstract. Population: Yes; evidence: “central bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “Five patients were treated with corticosteroids combined with antifungal therapy.”; source: title and abstract. Comparator: No; evidence: “Five patients were treated with corticosteroids combined with antifungal therapy.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “All cases had increased total serum IgE levels (median 3040 U/ml) and peripheral blood eosinophil count (median 0.19).”; source: title and abstract.", "evidenceQuotes": [ "The clinical presentations, serologic results, chest radiology, pathological results and treatment of 7 patients with ABPA in Chinese PLA General Hospital were retrospectively analyzed.", "central bronchiectasis", "Five patients were treated with corticosteroids combined with antifungal therapy.", "Five patients were treated with corticosteroids combined with antifungal therapy.", "All cases had increased total serum IgE levels (median 3040 U/ml) and peripheral blood eosinophil count (median 0.19)." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22847639", "title": "Interstitial Pneumonia associated with ulcerative colitis: high-resolution computed tomography and pathologic findings.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “We present a case of interstitial pneumonia associated with UC in a 61-year-old nonsmoking woman.”; source: title and abstract. Population: No; evidence: “traction bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “We also discuss the evaluation and treatment of pulmonary disease possibly related to UC in the clinical course of this patient.”; source: title and abstract. Comparator: No; evidence: “We also discuss the evaluation and treatment of pulmonary disease possibly related to UC in the clinical course of this patient.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Pulmonary parenchymal manifestations associated with ulcerative colitis (UC) include various conditions such as opportunistic infections, interstitial pneumonia, organizing pneumonia, and adverse drug reactions.”; source: title and abstract.", "evidenceQuotes": [ "We present a case of interstitial pneumonia associated with UC in a 61-year-old nonsmoking woman.", "traction bronchiectasis", "We also discuss the evaluation and treatment of pulmonary disease possibly related to UC in the clinical course of this patient.", "We also discuss the evaluation and treatment of pulmonary disease possibly related to UC in the clinical course of this patient.", "Pulmonary parenchymal manifestations associated with ulcerative colitis (UC) include various conditions such as opportunistic infections, interstitial pneumonia, organizing pneumonia, and adverse drug reactions." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18638625", "title": "Bronchiectasis-clinical cases.", "abstractAvailable": false, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Bronchiectasis-clinical cases.”; source: title and abstract. Population: Yes; evidence: “Bronchiectasis-clinical cases.”; source: title and abstract. Intervention or exposure: No; evidence: “Bronchiectasis-clinical cases.”; source: title and abstract. Comparator: No; evidence: “Bronchiectasis-clinical cases.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Bronchiectasis-clinical cases.”; source: title and abstract.", "evidenceQuotes": [ "Bronchiectasis-clinical cases.", "Bronchiectasis-clinical cases.", "Bronchiectasis-clinical cases.", "Bronchiectasis-clinical cases.", "Bronchiectasis-clinical cases." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26453629", "title": "Multiple breath washouts in children can be shortened without compromising quality.", "abstractAvailable": false, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “Multiple breath washouts in children can be shortened without compromising quality.”; source: title and abstract. Population: No; evidence: “Multiple breath washouts in children”; source: title and abstract. Intervention or exposure: No; evidence: “Multiple breath washouts”; source: title and abstract. Comparator: No; evidence: “Multiple breath washouts”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Multiple breath washouts in children”; source: title and abstract.", "evidenceQuotes": [ "Multiple breath washouts in children can be shortened without compromising quality.", "Multiple breath washouts in children", "Multiple breath washouts", "Multiple breath washouts", "Multiple breath washouts in children" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11106225", "title": "Clinical aspects of exhaled nitric oxide.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “There has been intense research into the role nitric oxide (NO) plays...”; source: title and abstract. Population: Maybe; evidence: “patients with unstable COPD, or bronchiectasis have high NO levels”; source: title and abstract. Intervention or exposure: No; evidence: “Exhaled NO has been successfully used to monitor anti-inflammatory treatment with inhaled corticosteroids in asthma.”; source: title and abstract. Comparator: No; evidence: “Exhaled NO is significantly elevated in acute asthma, or steroid-resistant severe asthma, or when the maintenance dose of inhaled steroids is reduced”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Exhaled and nasal NO are diagnostically low in cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "There has been intense research into the role nitric oxide (NO) plays...", "patients with unstable COPD, or bronchiectasis have high NO levels", "Exhaled NO has been successfully used to monitor anti-inflammatory treatment with inhaled corticosteroids in asthma.", "Exhaled NO is significantly elevated in acute asthma, or steroid-resistant severe asthma, or when the maintenance dose of inhaled steroids is reduced", "Exhaled and nasal NO are diagnostically low in cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10796717", "title": "Oral steroids for cystic fibrosis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “All randomised or pseudorandomised trials comparing oral corticosteroids...”; source: title and abstract. Population: No; evidence: “In cystic fibrosis, airway obstruction and recurrent respiratory infection leads to inflammation and eventually long term lung damage, (bronchiectasis)”; source: title and abstract. Intervention or exposure: No; evidence: “oral corticosteroids”; source: title and abstract. Comparator: Yes; evidence: “with placebo or no additional therapy”; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “In cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "All randomised or pseudorandomised trials comparing oral corticosteroids...", "In cystic fibrosis, airway obstruction and recurrent respiratory infection leads to inflammation and eventually long term lung damage, (bronchiectasis)", "oral corticosteroids", "with placebo or no additional therapy", "In cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20172263", "title": "The spectrum of nonasthmatic inflammatory airway diseases in adults.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Diseases associated with chronic productive cough discussed in this article include chronic bronchitis, bronchiectasis, and infectious and noninfectious bronchiolitis and their diagnosis and treatment.”; source: title and abstract. Population: Maybe; evidence: “chronic bronchitis, bronchiectasis, and infectious and noninfectious bronchiolitis”; source: title and abstract. Intervention or exposure: No; evidence: “their diagnosis and treatment”; source: title and abstract. Comparator: No; evidence: “their diagnosis and treatment”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “chronic bronchitis, bronchiectasis, and infectious and noninfectious bronchiolitis”; source: title and abstract.", "evidenceQuotes": [ "Diseases associated with chronic productive cough discussed in this article include chronic bronchitis, bronchiectasis, and infectious and noninfectious bronchiolitis and their diagnosis and treatment.", "chronic bronchitis, bronchiectasis, and infectious and noninfectious bronchiolitis", "their diagnosis and treatment", "their diagnosis and treatment", "chronic bronchitis, bronchiectasis, and infectious and noninfectious bronchiolitis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25792635", "title": "Management of bronchiectasis in adults.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This review provides a critical update on the management of bronchiectasis focussing on emerging evidence and recent randomised controlled trials.”; source: title and abstract. Population: Yes; evidence: “bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: “inhaled therapies”; source: title and abstract. Comparator: No; evidence: “randomised controlled trials have now demonstrated the benefit of long-term macrolide therapy”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "This review provides a critical update on the management of bronchiectasis focussing on emerging evidence and recent randomised controlled trials.", "bronchiectasis", "inhaled therapies", "randomised controlled trials have now demonstrated the benefit of long-term macrolide therapy", "bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24211131", "title": "Frequency of acute worsening events in fibrotic pulmonary sarcoidosis patients.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “In a retrospective manner”; source: title and abstract. Population: No; evidence: “fibrotic pulmonary sarcoidosis patients”; source: title and abstract. Intervention or exposure: No; evidence: “increased corticosteroid doses”; source: title and abstract. Comparator: No; evidence: “There was no relationship between the number of acute worsening events and race, gender, smoking history, or FVC, FEV1, or FEV1/FVC ratio.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “fibrotic pulmonary sarcoidosis patients”; source: title and abstract.", "evidenceQuotes": [ "In a retrospective manner", "fibrotic pulmonary sarcoidosis patients", "increased corticosteroid doses", "There was no relationship between the number of acute worsening events and race, gender, smoking history, or FVC, FEV1, or FEV1/FVC ratio.", "fibrotic pulmonary sarcoidosis patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "27143164", "title": "Cytokine profile of nasal and middle ear polyps in a patient with Woakes' syndrome and eosinophilic otitis media.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present a case”; source: title and abstract. Population: No; evidence: “Woakes' syndrome is characterised by severe recurrent nasal polyps in early childhood with broadening of the nose, nasal dyscrinia, frontal sinus aplasia and bronchiectasis.”; source: title and abstract. Intervention or exposure: No; evidence: “both diseases must be recognised and treated appropriately”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Woakes' syndrome”; source: title and abstract.", "evidenceQuotes": [ "We present a case", "Woakes' syndrome is characterised by severe recurrent nasal polyps in early childhood with broadening of the nose, nasal dyscrinia, frontal sinus aplasia and bronchiectasis.", "both diseases must be recognised and treated appropriately", "Woakes' syndrome" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16369404", "title": "Kartagener's syndrome associated with allergic bronchopulmonary aspergillosis.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: No abstract available; cannot determine study design.; source: title and abstract. Population: Maybe; evidence: “Kartagener's syndrome associated with allergic bronchopulmonary aspergillosis”; source: title and abstract. Intervention or exposure: Maybe; evidence: No abstract; cannot determine intervention.; source: title and abstract. Comparator: Maybe; evidence: No abstract; cannot determine comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No abstract; cannot determine if CF is excluded.; source: title and abstract.", "evidenceQuotes": [ "Kartagener's syndrome associated with allergic bronchopulmonary aspergillosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22396571", "title": "Bronchiectasis: defining specific treatment needs.", "abstractAvailable": false, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: No abstract; cannot determine study design.; source: title and abstract. Population: Maybe; evidence: “Bronchiectasis: defining specific treatment needs”; source: title and abstract. Intervention or exposure: Maybe; evidence: No abstract; cannot determine intervention.; source: title and abstract. Comparator: Maybe; evidence: No abstract; cannot determine comparator.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: No abstract; cannot determine if CF is excluded.; source: title and abstract.", "evidenceQuotes": [ "Bronchiectasis: defining specific treatment needs" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "18592990", "title": "[Case of bronchocentric granulomatosis that became recognized in the course of allergic bronchopulmonary aspergillosis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 56-year-old man with allergic bronchopulmonary aspergillosis (ABPA) was admitted”; source: title and abstract. Population: No; evidence: “bilateral bronchiectasis with mucoid impactions”; source: title and abstract. Intervention or exposure: No; evidence: “Treatment with corticosteroids and micafungin sodium”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “allergic bronchopulmonary aspergillosis”; source: title and abstract.", "evidenceQuotes": [ "A 56-year-old man with allergic bronchopulmonary aspergillosis (ABPA) was admitted", "bilateral bronchiectasis with mucoid impactions", "Treatment with corticosteroids and micafungin sodium", "allergic bronchopulmonary aspergillosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22684355", "title": "Budesonide efficacy and safety in patients with bronchiectasis not due to cystic fibrosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: Yes; evidence: “patients with bronchiectasis not due to cystic fibrosis”; source: title and abstract. Intervention or exposure: Yes; evidence: “receive either 400 mcg budesonide twice daily or placebo”; source: title and abstract. Comparator: Yes; evidence: “or placebo”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “not due to cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "patients with bronchiectasis not due to cystic fibrosis", "receive either 400 mcg budesonide twice daily or placebo", "or placebo", "not due to cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17353121", "title": "Interstitial lung disease associated with amyopathic dermatomyositis: review of 18 cases.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Eighteen patients diagnosed with ILD associated with ADM were assigned to 1 of 2 groups”; source: title and abstract. Population: No; evidence: “Interstitial lung disease associated with amyopathic dermatomyositis”; source: title and abstract. Intervention or exposure: No; evidence: “intensive treatment”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Eighteen patients diagnosed with ILD associated with ADM were assigned to 1 of 2 groups", "Interstitial lung disease associated with amyopathic dermatomyositis", "intensive treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23188194", "title": "Pulmonary involvement in ANCA-associated vasculitis from the view of the pulmonologist.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “ANCA-associated vasculitis”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroid”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "ANCA-associated vasculitis", "corticosteroid" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15581196", "title": "Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Yes; evidence: “randomised to receive either fluticasone (1 mg/daily) or identical placebo”; source: title and abstract. Population: Yes; evidence: “Stable non-smoking bronchiectasis patients”; source: title and abstract. Intervention or exposure: Yes; evidence: “fluticasone (1 mg/daily)”; source: title and abstract. Comparator: Yes; evidence: “identical placebo”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "randomised to receive either fluticasone (1 mg/daily) or identical placebo", "Stable non-smoking bronchiectasis patients", "fluticasone (1 mg/daily)", "identical placebo" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10731875", "title": "Allergic bronchopulmonary aspergillosis in two patients with cystic fibrosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We present two cystic fibrosis patients”; source: title and abstract. Population: No; evidence: “two cystic fibrosis patients”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “two cystic fibrosis patients”; source: title and abstract.", "evidenceQuotes": [ "We present two cystic fibrosis patients", "two cystic fibrosis patients", "two cystic fibrosis patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "24913725", "title": "Combination inhaled corticosteroids and long-acting beta2-agonists for children and adults with bronchiectasis.", "abstractAvailable": true, "decision": "include", "recommendation": "include", "confidence": "high", "rationale": "Title-and-abstract screening: retain for the next stage. Study design: Yes; evidence: “All randomised controlled trials (RCTs) of combined ICS and LABA compared with a control (placebo, no treatment, ICS as monotherapy) in children and adults with bronchiectasis not related to cystic fibrosis (CF).”; source: title and abstract. Population: Yes; evidence: “children and adults with bronchiectasis not related to cystic fibrosis (CF)”; source: title and abstract. Intervention or exposure: Yes; evidence: “combined ICS-LABA”; source: title and abstract. Comparator: Yes; evidence: “compared with a control (placebo, no treatment, ICS as monotherapy)”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “not related to cystic fibrosis (CF)”; source: title and abstract.", "evidenceQuotes": [ "All randomised controlled trials (RCTs) of combined ICS and LABA compared with a control (placebo, no treatment, ICS as monotherapy) in children and adults with bronchiectasis not related to cystic fibrosis (CF).", "children and adults with bronchiectasis not related to cystic fibrosis (CF)", "combined ICS-LABA", "compared with a control (placebo, no treatment, ICS as monotherapy)", "not related to cystic fibrosis (CF)" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17193861", "title": "[Norwegian scabies, a rare diagnosis in Tunisia].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report an observation of norwegian scabies”; source: title and abstract. Population: No; evidence: “a 65-year-old woman, with a long history of obstructive bronchoneumopathy and bronchiectasis”; source: title and abstract. Intervention or exposure: No; evidence: “treated with systemic corticosteroids for 5 years”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report an observation of norwegian scabies", "a 65-year-old woman, with a long history of obstructive bronchoneumopathy and bronchiectasis", "treated with systemic corticosteroids for 5 years" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "21500868", "title": "Targeting airway inflammation in cystic fibrosis in children: past, present, and future.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Anti-inflammatory drugs for CF lung disease appear to have beneficial effects on disease progression.”; source: title and abstract. Population: No; evidence: “cystic fibrosis (CF) pulmonary disease”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: No comparator is specified.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “cystic fibrosis (CF) pulmonary disease”; source: title and abstract.", "evidenceQuotes": [ "Anti-inflammatory drugs for CF lung disease appear to have beneficial effects on disease progression.", "cystic fibrosis (CF) pulmonary disease", "Inhaled corticosteroids", "cystic fibrosis (CF) pulmonary disease" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7881674", "title": "Ciliary disorientation in patients with chronic upper respiratory tract inflammation.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This study investigated groups of patients”; source: title and abstract. Population: Yes; evidence: “15 patients with idiopathic bronchiectasis and chronic mucopurulent sinusitis, 12 patients with cystic fibrosis”; source: title and abstract. Intervention or exposure: No; evidence: “Treatment of one patient with antibiotics and topical corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “12 patients with cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "This study investigated groups of patients", "15 patients with idiopathic bronchiectasis and chronic mucopurulent sinusitis, 12 patients with cystic fibrosis", "Treatment of one patient with antibiotics and topical corticosteroids", "12 patients with cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "3882313", "title": "Cathepsin B-like cysteine proteinase activity in sputum and bronchoalveolar lavage samples: relationship to inflammatory cells and effects of corticosteroids and antibiotic treatment.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Enzyme activity in the sputum from ten subjects with chronic bronchitis was significantly reduced after 5 days' treatment with prednisolone.”; source: title and abstract. Population: Yes; evidence: “Seven patients with bronchiectasis were studied”; source: title and abstract. Intervention or exposure: No; evidence: “treatment with prednisolone”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Enzyme activity in the sputum from ten subjects with chronic bronchitis was significantly reduced after 5 days' treatment with prednisolone.", "Seven patients with bronchiectasis were studied", "treatment with prednisolone" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7267968", "title": "Chronic bronchial suppuration and inflammatory bowel disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Seven patients with severe, unexplained chronic bronchial suppuration and inflammatory bowel disease are reported.”; source: title and abstract. Population: Yes; evidence: “Seven patients with severe, unexplained chronic bronchial suppuration and inflammatory bowel disease are reported. In three, rapidly progressive bronchiectasis developed within one year of procto-colectomy”; source: title and abstract. Intervention or exposure: No; evidence: “In the four patients who received corticosteroid therapy there was an impressive improvement in cough, sputum volume and dyspnoea, especially when taking high doses.”; source: title and abstract. Comparator: No; evidence: “In the four patients who received corticosteroid therapy there was an impressive improvement in cough, sputum volume and dyspnoea, especially when taking high doses.”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Seven patients with severe, unexplained chronic bronchial suppuration and inflammatory bowel disease are reported.", "Seven patients with severe, unexplained chronic bronchial suppuration and inflammatory bowel disease are reported. In three, rapidly progressive bronchiectasis developed within one year of procto-colectomy", "In the four patients who received corticosteroid therapy there was an impressive improvement in cough, sputum volume and dyspnoea, especially when taking high doses.", "In the four patients who received corticosteroid therapy there was an impressive improvement in cough, sputum volume and dyspnoea, especially when taking high doses." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16434174", "title": "Inhaled steroids improve quality of life in patients with steady-state bronchiectasis.", "abstractAvailable": true, "decision": "include", "recommendation": "include", "confidence": "high", "rationale": "Title-and-abstract screening: retain for the next stage. Study design: Yes; evidence: “Prospective, randomized, double-blind (for effective doses) study.”; source: title and abstract. Population: Yes; evidence: “patients with steady-state bronchiectasis not due to cystic fibrosis”; source: title and abstract. Intervention or exposure: Yes; evidence: “randomized to receive 250 microg bid, 500 microg bid or no treatment with inhaled FP for 6 months”; source: title and abstract. Comparator: Yes; evidence: “or no treatment with inhaled FP”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “not due to cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "Prospective, randomized, double-blind (for effective doses) study.", "patients with steady-state bronchiectasis not due to cystic fibrosis", "randomized to receive 250 microg bid, 500 microg bid or no treatment with inhaled FP for 6 months", "or no treatment with inhaled FP", "not due to cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19953044", "title": "[Pulmonary fibrosis as a presentation of Wegener's granulomatosis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Case report: We report the case of an 82-year-old man presenting with pulmonary fibrosis.”; source: title and abstract. Population: No; evidence: “The CT scan showed honeycombing and traction bronchiectasis with peripheral and basal predominance.”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Case report: We report the case of an 82-year-old man presenting with pulmonary fibrosis.", "The CT scan showed honeycombing and traction bronchiectasis with peripheral and basal predominance." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7721084", "title": "Diagnosis and management of allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Early diagnosis and treatment is essential for patients afflicted with bronchopulmonary aspergillosis (ABPA).”; source: title and abstract. Population: No; evidence: “ABPA should be considered in any asthmatic who requires oral corticosteroids and has recurrent pulmonary infiltrates.”; source: title and abstract. Intervention or exposure: No; evidence: “The treatment choice for ABPA is prednisone, although inhaled corticosteroids including beclomethasone dipropionate may also be used in long-term asthma management.”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Early diagnosis and treatment is essential for patients afflicted with bronchopulmonary aspergillosis (ABPA).", "ABPA should be considered in any asthmatic who requires oral corticosteroids and has recurrent pulmonary infiltrates.", "The treatment choice for ABPA is prednisone, although inhaled corticosteroids including beclomethasone dipropionate may also be used in long-term asthma management." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "27543875", "title": "Shulman disease (eosinophilic fasciitis) in X-linked agammaglobulinemia.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Our patient was diagnosed with XLA in the first year of life, followed by regular substitution of immunoglobulins.”; source: title and abstract. Population: No; evidence: “in the majority of patients bronchiectasis and chronic sinusitis with an overgrown mucous membrane develop despite regular substitution.”; source: title and abstract. Intervention or exposure: No; evidence: “After the diagnosis, therapy included steroids, immunoglobulins in a high dose and immunosuppression”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Our patient was diagnosed with XLA in the first year of life, followed by regular substitution of immunoglobulins.", "in the majority of patients bronchiectasis and chronic sinusitis with an overgrown mucous membrane develop despite regular substitution.", "After the diagnosis, therapy included steroids, immunoglobulins in a high dose and immunosuppression" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26008663", "title": "Therapeutic bronchoalveolar lavage with conventional treatment in allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Study design: Aquasi-experimental study.”; source: title and abstract. Population: No; evidence: “patients with allergic bronchopulmonary aspergillosis”; source: title and abstract. Intervention or exposure: No; evidence: “All patients were given treatment including prednisolone and antifungal agent itraconazole for 4 months.”; source: title and abstract. Comparator: No; evidence: “Patients with ORF on HRCTchest and just received the medical treatment were labeled as conventional group.”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Study design: Aquasi-experimental study.", "patients with allergic bronchopulmonary aspergillosis", "All patients were given treatment including prednisolone and antifungal agent itraconazole for 4 months.", "Patients with ORF on HRCTchest and just received the medical treatment were labeled as conventional group." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25712512", "title": "Allergic bronchopulmonary aspergillosis in children.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Here we report the case of a 13-year-old girl”; source: title and abstract. Population: No; evidence: “13-year-old girl with ABPA who presented with productive cough, bronchiectasis and decline in lung function”; source: title and abstract. Intervention or exposure: No; evidence: “review the clinical features and treatment for pediatric ABPA”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Here we report the case of a 13-year-old girl", "13-year-old girl with ABPA who presented with productive cough, bronchiectasis and decline in lung function", "review the clinical features and treatment for pediatric ABPA" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "25854336", "title": "Radiation induced lung injury: prediction, assessment and management.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Radiation induced lung injury has long been considered a treatment limiting factor”; source: title and abstract. Population: No; evidence: “patients requiring thoracic radiation”; source: title and abstract. Intervention or exposure: No; evidence: “Steroids, ACE inhibitors and pentoxyphylline constitute the cornerstone of therapy.”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Radiation induced lung injury has long been considered a treatment limiting factor", "patients requiring thoracic radiation", "Steroids, ACE inhibitors and pentoxyphylline constitute the cornerstone of therapy." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23448773", "title": "Successful treatment with tacrolimus in a case of lung-dominant connective tissue disease.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 49-year-old man with dyspnea was found to have reticular opacities”; source: title and abstract. Population: No; evidence: “lung-dominant connective tissue disease (LD-CTD)”; source: title and abstract. Intervention or exposure: No; evidence: “therapy was initiated with corticosteroids in combination with cyclosporine A”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 49-year-old man with dyspnea was found to have reticular opacities", "lung-dominant connective tissue disease (LD-CTD)", "therapy was initiated with corticosteroids in combination with cyclosporine A" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "4006557", "title": "Adult bronchiolitis. Evaluation by bronchoalveolar lavage and response to prednisone therapy.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Four adult patients with biopsy-proven bronchiolitis were identified and prospectively evaluated.”; source: title and abstract. Population: No; evidence: “Four adult patients with biopsy-proven bronchiolitis”; source: title and abstract. Intervention or exposure: No; evidence: “treatment with 1 mg/kg/day of prednisone”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Four adult patients with biopsy-proven bronchiolitis were identified and prospectively evaluated.", "Four adult patients with biopsy-proven bronchiolitis", "treatment with 1 mg/kg/day of prednisone" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "12045132", "title": "Acute interstitial pneumonia: comparison of high-resolution computed tomography findings between survivors and nonsurvivors.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “This study compared high-resolution computed tomography (CT) findings between 10 survivors and 21 nonsurvivors of acute interstitial pneumonia”; source: title and abstract. Population: No; evidence: “acute interstitial pneumonia”; source: title and abstract. Intervention or exposure: No; evidence: “evaluated whether the CT findings were predictive of patients' response to treatment”; source: title and abstract. Comparator: No; evidence: “between survivors and nonsurvivors”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "This study compared high-resolution computed tomography (CT) findings between 10 survivors and 21 nonsurvivors of acute interstitial pneumonia", "acute interstitial pneumonia", "evaluated whether the CT findings were predictive of patients' response to treatment", "between survivors and nonsurvivors" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "17943909", "title": "Oral non steroid anti-inflammatories for children and adults with bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “No randomised or controlled trials were found.”; source: title and abstract. Population: Yes; evidence: “children and adults with bronchiectasis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: Comparator not specified in abstract.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “Patients with Cystic Fibrosis were excluded.”; source: title and abstract.", "evidenceQuotes": [ "No randomised or controlled trials were found.", "children and adults with bronchiectasis", "Patients with Cystic Fibrosis were excluded." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "14512672", "title": "Postinfectious bronchiolitis obliterans in children: clinical and radiological profile and prognostic factors.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We undertook a review of the medical records of 20 children”; source: title and abstract. Population: No; evidence: “postinfectious bronchiolitis obliterans”; source: title and abstract. Intervention or exposure: No; evidence: “Corticosteroid therapy was used in 17 patients”; source: title and abstract. Comparator: No; evidence: “supportive treatment was applied in all patients”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We undertook a review of the medical records of 20 children", "postinfectious bronchiolitis obliterans", "Corticosteroid therapy was used in 17 patients", "supportive treatment was applied in all patients" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "22445696", "title": "Serologic allergic bronchopulmonary aspergillosis (ABPA-S): long-term outcomes.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “retrospective study”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: No; evidence: “treated with glucocorticoids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "retrospective study", "treated with glucocorticoids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "15996182", "title": "Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “chronic obstructive pulmonary disease, cystic fibrosis, acute respiratory distress syndrome, bronchiectasis and non-eosinophilic bronchial asthma”; source: title and abstract. Intervention or exposure: No; evidence: “corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: No; evidence: “cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "chronic obstructive pulmonary disease, cystic fibrosis, acute respiratory distress syndrome, bronchiectasis and non-eosinophilic bronchial asthma", "corticosteroids", "cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "395813", "title": "Light- and scanning electron-microscopy of the nasal mucosa.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The article is a short review”; source: title and abstract. Population: Maybe; evidence: The abstract mentions nasal mucosa and rhinitis patients, but does not specify bronchiectasis.; source: title and abstract. Intervention or exposure: Maybe; evidence: “continuously treated with topically active steroids”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The article is a short review", "continuously treated with topically active steroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "10796575", "title": "Inhaled steroids for bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Yes; evidence: “Only randomised double blind studies controlled trials were included.”; source: title and abstract. Population: Yes; evidence: “Patients with radiographic evidence of bronchiectasis were included, but patients with cystic fibrosis were excluded.”; source: title and abstract. Intervention or exposure: Yes; evidence: “regular inhaled corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The abstract does not explicitly state the comparator, but as a review of RCTs, it likely includes placebo or no medication. However, not directly stated.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “patients with cystic fibrosis were excluded”; source: title and abstract.", "evidenceQuotes": [ "Only randomised double blind studies controlled trials were included.", "Patients with radiographic evidence of bronchiectasis were included, but patients with cystic fibrosis were excluded.", "regular inhaled corticosteroids", "patients with cystic fibrosis were excluded" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19450337", "title": "Bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We conducted a systematic review”; source: title and abstract. Population: Yes; evidence: “people with bronchiectasis but without cystic fibrosis”; source: title and abstract. Intervention or exposure: Maybe; evidence: “steroids (inhaled, oral)”; source: title and abstract. Comparator: Maybe; evidence: No comparator specified.; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “without cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "We conducted a systematic review", "people with bronchiectasis but without cystic fibrosis", "steroids (inhaled, oral)", "without cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1416399", "title": "Chest radiography and high resolution computed tomography of the lungs in asthma.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Population: No; evidence: “chronic asthma”; source: title and abstract. Intervention or exposure: No; evidence: “parenteral high dose corticosteroid treatment”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "chronic asthma", "parenteral high dose corticosteroid treatment" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11844130", "title": "Allergic bronchopulmonary aspergillosis: a rare cause of pleural effusion.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report the case of a patient”; source: title and abstract. Population: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Intervention or exposure: No; evidence: “commenced on prednisolone”; source: title and abstract. Comparator: Maybe; evidence: No comparator mentioned.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: “ABPA is a syndrome seen in patients with asthma and cystic fibrosis”; source: title and abstract.", "evidenceQuotes": [ "We report the case of a patient", "commenced on prednisolone", "ABPA is a syndrome seen in patients with asthma and cystic fibrosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "20298395", "title": "Bronchiectasis: an update.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Search was limited to randomized control trials, clinical trials, meta-analysis, reviews published in English”; source: title and abstract. Population: Maybe; evidence: “Bronchiectasis is defined as an abnormal and irreversible dilatation of the bronchi”; source: title and abstract. Intervention or exposure: No; evidence: “Therapy is aimed to limit the cycle of infection and inflammation”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Search was limited to randomized control trials, clinical trials, meta-analysis, reviews published in English", "Bronchiectasis is defined as an abnormal and irreversible dilatation of the bronchi", "Therapy is aimed to limit the cycle of infection and inflammation" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19160186", "title": "Inhaled steroids for bronchiectasis.", "abstractAvailable": true, "decision": "include", "recommendation": "include", "confidence": "high", "rationale": "Title-and-abstract screening: retain for the next stage. Study design: Yes; evidence: “All randomised controlled trials comparing ICS with a placebo or no medication.”; source: title and abstract. Population: Yes; evidence: “Children and adults with clinical or radiographic evidence of bronchiectasis were included, but patients with cystic fibrosis (CF) were excluded.”; source: title and abstract. Intervention or exposure: Yes; evidence: “inhaled corticosteroids (ICS)”; source: title and abstract. Comparator: Yes; evidence: “comparing ICS with a placebo or no medication.”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “patients with cystic fibrosis (CF) were excluded.”; source: title and abstract.", "evidenceQuotes": [ "All randomised controlled trials comparing ICS with a placebo or no medication.", "Children and adults with clinical or radiographic evidence of bronchiectasis were included, but patients with cystic fibrosis (CF) were excluded.", "inhaled corticosteroids (ICS)", "comparing ICS with a placebo or no medication.", "patients with cystic fibrosis (CF) were excluded." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "1470705", "title": "Pulmonary eosinophilia with systemic features: therapy and prognosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Of 65 patients presenting with pulmonary eosinophilia to one Respiratory Unit during a 20-year period”; source: title and abstract. Population: No; evidence: “pulmonary eosinophilia”; source: title and abstract. Intervention or exposure: No; evidence: “Steroid therapy achieved a good clinical response”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Of 65 patients presenting with pulmonary eosinophilia to one Respiratory Unit during a 20-year period", "pulmonary eosinophilia", "Steroid therapy achieved a good clinical response" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "8367756", "title": "Pneumothorax and bronchopleural fistula during treatment of allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A man with allergic bronchopulmonary aspergillosis had pneumothorax and bronchopleural fistula”; source: title and abstract. Population: No; evidence: “allergic bronchopulmonary aspergillosis”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A man with allergic bronchopulmonary aspergillosis had pneumothorax and bronchopleural fistula", "allergic bronchopulmonary aspergillosis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26250371", "title": "Allergic bronchopulmonary aspergillosis in an adult with Kartagener syndrome.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “We report a case of ABPA in an adult suffering from Kartagener syndrome.”; source: title and abstract. Population: No; evidence: “Kartagener syndrome”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "We report a case of ABPA in an adult suffering from Kartagener syndrome.", "Kartagener syndrome" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "11583057", "title": "Current pharmacotherapy of allergic bronchopulmonary aspergillosis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “Although no well-designed studies have been carried out”; source: title and abstract. Population: No; evidence: “allergic bronchopulmonary aspergillosis (ABPA)”; source: title and abstract. Intervention or exposure: No; evidence: “use of corticosteroids for acute exacerbations”; source: title and abstract. Comparator: No; evidence: “no well-designed studies”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "Although no well-designed studies have been carried out", "allergic bronchopulmonary aspergillosis (ABPA)", "use of corticosteroids for acute exacerbations", "no well-designed studies" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "16208427", "title": "Follicular bronchiolitis, an unusual cause of haemoptysis in giant cell arteritis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “A 64-year-old man with long-standing GCA subsequently presented with haemoptysis.”; source: title and abstract. Population: No; evidence: “Follicular bronchiolitis, an unusual cause of haemoptysis in giant cell arteritis.”; source: title and abstract. Intervention or exposure: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "A 64-year-old man with long-standing GCA subsequently presented with haemoptysis.", "Follicular bronchiolitis, an unusual cause of haemoptysis in giant cell arteritis." ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "26293490", "title": "Association between inhaler use and risk of haemoptysis in patients with non-cystic fibrosis bronchiectasis.", "abstractAvailable": true, "decision": "exclude", "recommendation": "exclude", "confidence": "high", "rationale": "Title-and-abstract screening: exclude. Study design: No; evidence: “A nested case-control study was performed”; source: title and abstract. Population: Yes; evidence: “patients with non-cystic fibrosis bronchiectasis”; source: title and abstract. Intervention or exposure: Yes; evidence: “Inhalers including inhaled corticosteroids (ICS)”; source: title and abstract. Comparator: No; evidence: “strictly matched controls”; source: title and abstract. Exclusion criterion 1 not triggered: Yes; evidence: “non-cystic fibrosis bronchiectasis”; source: title and abstract.", "evidenceQuotes": [ "A nested case-control study was performed", "patients with non-cystic fibrosis bronchiectasis", "Inhalers including inhaled corticosteroids (ICS)", "strictly matched controls", "non-cystic fibrosis bronchiectasis" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "7415584", "title": "[Susceptibility for infections in patients with chronic polyarthritis].", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “The case histories and autopsy findings of 79 patients”; source: title and abstract. Population: No; evidence: “patients with rheumatoid arthritis (RA)”; source: title and abstract. Intervention or exposure: No; evidence: “long term corticoid treatment”; source: title and abstract. Comparator: No; evidence: “compared with an exactly matched control group”; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "The case histories and autopsy findings of 79 patients", "patients with rheumatoid arthritis (RA)", "long term corticoid treatment", "compared with an exactly matched control group" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "23889240", "title": "Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “review of literature”; source: title and abstract. Population: No; evidence: “Allergic bronchopulmonary aspergillosis (ABPA)”; source: title and abstract. Intervention or exposure: No; evidence: “oral corticosteroids”; source: title and abstract. Comparator: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "review of literature", "Allergic bronchopulmonary aspergillosis (ABPA)", "oral corticosteroids" ] }, { "topicId": "CD000996", "task": "Intervention", "pmid": "19659645", "title": "Clinical challenges in managing bronchiectasis.", "abstractAvailable": true, "decision": "unsure", "recommendation": "unsure", "confidence": "low", "rationale": "Title-and-abstract screening: manual review required. Study design: No; evidence: “There are only very few trials.”; source: title and abstract. Population: Yes; evidence: “Bronchiectasis is a common disease in the Asia-Pacific and affected patients suffer from chronic sputum production and recurrent exacerbations.”; source: title and abstract. Intervention or exposure: Maybe; evidence: “Existing data suggest some efficacy of inhaled corticosteroid therapy”; source: title and abstract. Comparator: Maybe; evidence: No comparator is mentioned in the abstract.; source: title and abstract. Exclusion criterion 1 not triggered: Maybe; evidence: The model did not provide a quote verifiable in the title or abstract; manual review is required.; source: title and abstract.", "evidenceQuotes": [ "There are only very few trials.", "Bronchiectasis is a common disease in the Asia-Pacific and affected patients suffer from chronic sputum production and recurrent exacerbations.", "Existing data suggest some efficacy of inhaled corticosteroid therapy" ] } ]