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3. GLP-1 receptor agonists and weight outcomes
Across the included trials, semaglutide 2.4 mg was consistently associated with clinically meaningful weight reduction versus placebo. The STEP 1 trial reported a mean change of −14.9% at 68 weeks[1], while sustained treatment in STEP 5 maintained −15.2% at two years[2]. Discontinuation was followed by substantial weight regain in the extension analysis[3], suggesting that treatment persistence is a key mediator of long-term outcomes.
Gastrointestinal adverse events were the most frequently reported safety signal across trials[1][4], though discontinuation rates remained below 7% in most study arms.
References (from your selected papers)
- [1] Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021.
- [2] Garvey WT, et al. Two-year effects of semaglutide in adults with overweight or obesity (STEP 5). Nat Med. 2022.
- + 14 more selected papers…
Citation Audit
The audit checks each claim against your selected papers and flags anything with weak support — before you export.
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Semaglutide for obesity: complete PRISMA-lite walkthrough
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Papers ranked by how well they answer your question.
Sleep deprivation significantly impairs cognitive function, particularly working memory and sustained attention.
According to Smith (2023), acute sleep loss disrupts prefrontal cortex connectivity.
Audit-ready Draft
A structured review where each citation can be traced back to evidence.
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Every citation links to the source. Check it yourself.
"We observed a correlation coefficient of r = 0.82 (p < 0.001) between variable X and Y across all 3 cohorts."
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