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Biomedical systematic review

Build a PubMed systematic review from screening to cited synthesis

Move beyond a narrative PubMed search into a structured PRISMA-lite workflow: define eligibility criteria, screen with AI support, extract evidence, and draft a cited synthesis.

Start your review Search papers
What this tool helps you do

A PubMed systematic review requires more than searching and summarizing. LitSynth adds protocol definition, AI-assisted title and abstract screening, structured evidence extraction, and a cited synthesis draft with a citation audit, so biomedical reviewers can move from question to draft in one connected workflow while keeping every decision inspectable.

Editable workflow

From research question to a review you can inspect

Each stage stays visible, so you can revise the scope or evidence choices before generating again.

  1. 1

    Enter a biomedical research question and confirm eligibility criteria.

  2. 2

    Retrieve and screen candidate records with AI decision support.

  3. 3

    Extract structured evidence from included papers.

  4. 4

    Generate a cited synthesis with PRISMA-lite methods notes.

Best for

  • Biomedical researchers running a PRISMA-lite review on PubMed-sourced evidence
  • Teams that need screening, extraction, and synthesis connected
  • Clinicians drafting a rapid review before formal full-text appraisal

Not a replacement for

  • Replacing Cochrane-grade methodology or meta-analysis
  • Dual independent screening with formal conflict resolution
  • Making clinical decisions without expert appraisal

Facts on this page

Domain
Biomedical

optimized for PubMed-sourced clinical and health evidence

Rigor
PRISMA-lite

protocol, screening, extraction, and methods notes

Audit
Citation check

flags claims lacking support from selected evidence

Limits stated on this page

  • LitSynth does not provide medical advice or clinical recommendations.
  • PRISMA-lite is not full PRISMA 2020 compliance; formal reviews need registration and dual screening.
  • Database coverage should be verified against your protocol requirements.

Keep evidence decisions visible

LitSynth treats AI as support for a review process. You keep control of which papers enter the evidence set and which claims need another check.

Define a focused biomedical question with eligibility criteria.

Screen retrieved records with AI relevance scoring and recommendations.

Extract study design, population, outcomes, and limitations per paper.

Generate a PRISMA-lite synthesis with citations and audit notes.

Questions researchers ask

How is this different from the PubMed literature review tool?

The PubMed literature review tool focuses on narrative review drafting from biomedical search results. This page covers the systematic review workflow: protocol definition, eligibility criteria, structured screening, evidence extraction into tables, and a PRISMA-lite synthesis with methods notes. Use the narrative tool for quick reviews; use this for reviews that need more rigor.

Can I use this for a Cochrane review?

No. LitSynth provides a PRISMA-lite workflow, not Cochrane-grade methodology. It does not support dual independent screening, meta-analysis, or risk-of-bias tools like RoB 2. Use it for rapid reviews, scoping reviews, or early drafts before formal full-text appraisal.

Does it search PubMed directly?

LitSynth retrieves academic papers including biomedical literature. You should verify that the retrieved coverage matches your protocol requirements, especially if you need specific database combinations like Embase, CINAHL, or Cochrane CENTRAL.

Can I see a biomedical example?

Yes. The semaglutide obesity systematic review example shows a complete PRISMA-lite workflow with screening numbers, evidence table, and citation audit on a biomedical topic.

Continue your research workflow

Screen with AI decision supportExtract evidence into tablesPubMed narrative literature review toolSee a biomedical example report

Build the review, then revise any step

Search papers, screen the evidence, generate a cited draft, and return to earlier decisions whenever the scope needs to change.

Start your review
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Research workflows

Explore focused guides for literature reviews, PubMed workflows, citation audits, and PRISMA-lite review planning.

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