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3. GLP-1 receptor agonists and weight outcomes
Across the included trials, semaglutide 2.4 mg was consistently associated with clinically meaningful weight reduction versus placebo. The STEP 1 trial reported a mean change of −14.9% at 68 weeks[1], while sustained treatment in STEP 5 maintained −15.2% at two years[2]. Discontinuation was followed by substantial weight regain in the extension analysis[3], suggesting that treatment persistence is a key mediator of long-term outcomes.
Gastrointestinal adverse events were the most frequently reported safety signal across trials[1][4], though discontinuation rates remained below 7% in most study arms.
参考文献（選択した論文から）
- [1] Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021.
- [2] Garvey WT, et al. Two-year effects of semaglutide in adults with overweight or obesity (STEP 5). Nat Med. 2022.
- + 14 more selected papers…
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